In our August issue:
COLUMNS
LC Troubleshooting
Pass the Salt: Evolution of Coupling Ion-Exchange Separations
and Mass Spectrometry
Dwight R. Stoll
The high levels of non-volatile salts typically used in ion-exchange separations are incompatible with mass spectrometry. But the desire to directly couple these two powerful techniques has prompted researchers find solutions to this problem. Here are three approaches.
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Increase Sensitivity and Reliability for Biopharmaceutical Applications by Simple Improvements in Sample Preparation
Thursday, August 29, 2019 at 11am EDT| 8am PDT | 4pm BST | 5pm CEST
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Sample Prep Perspectives
Looking at the Past to Understand the Future: Soxhlet Extraction
Douglas E. Raynie
To better understand modern sample preparation techniques—such as ultrasound-assisted extraction, microwave-assisted extraction, and pressurized solvent extraction—we should look at the lessons these methods took from Soxhlet extraction.
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A Revolutionary Approach to Light Scattering Technology
Thursday, August 22, 2019, at 11am EDT | 8am PDT | 4pm BST | 5pm CEST
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Perspectives in Modern HPLC
HPLC Autosamplers: Perspectives, Principles, and Practices
Carsten Paul, Frank Steiner, and Michael W. Dong
We explain recent trends in HPLC autosampler design, provide recommendations for selecting one, and offer guidelines for operation and troubleshooting.
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Comprehensive N-glycosylation Analysis During Biologics Manufacturing Focusing on Biosimilarity
Wednesday, August 21, 2019 at 11am EDT | 8am PDT | 4pm BST | 5pm CEST
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The Essentials
The Importance of Tuning and Calibration in Liquid Chromatography–Mass Spectrometry (LC–MS)
In LC–MS, the importance of tuning and calibrating the mass spectrometer cannot be overemphasized. There are six main aspects to address.
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Native MS for Aggregate and Charge Variant Analysis of Biotherapeutics
Tuesday, August 20, 2019 at 11am EDT | 8am PDT | 4pm BST | 5pm CEST
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Feature
Data Integrity Focus, Part VII: A Data Life Cycle for Chromatography
R.D. McDowall
Several regulatory data integrity guidance documents require that laboratories understand the data life cycle of their processes, but provide only vague definitions of what a data life cycle is. Here is a practical interpretation.
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What LC-MS Operators Need to Know
Thursday, August 15, 2019 at 11am EDT| 8am PDT| 4pm BST| 5pm CEST
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Peer-Reviewed Article
HILIC to the Rescue: Pharmaceutical Development Case Examples
Jonathan G. Shackman
HILIC has rapidly evolved into a practical technique. For analyzing highly polar compounds, HILIC can be far more straightforward than GC or reversed-phase LC with derivatization, and can lead to a simpler final method with robustness comparable to that of reversed-phase LC.
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| MORE ON DEMAND WEBCASTS |
Practical UHPLC: Selectivity and Rapid Method Development, Method Translations, and UHPLC Instrument Transfers
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A Useful Method Development Strategy for Structural Characterization of Large Protein Variants via Reversed-Phase Chromatography
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Leveraging Emerging Analytical Technologies to Improve Productivity in a Commercial Environmental Laboratory
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| LIVE WEBCAST |
Developing a Robust CQA Monitoring Method via Multi-Attribute Monitoring Principles for Therapeutic Monoclonal Antibody Development, Manufacturing, and Lifecycle Management
Tuesday, Sept. 10, 2019 at 11 am EDT | 8 am PDT | 4 pm BST | 5 pm CEST
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| ON DEMAND WEBCASTS |
Filtration in Dissolution Testing
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Determining an HPLC or UHPLC Selectivity Starting Point
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A Practical Guide to Analytical Method Development
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Ensuring GxP Data is Available and Enduring Throughout its Retention Period: High Availability, Disaster Recovery, and Business Continuity in Laboratory Operations
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Optimize Your GC Lab with On-Site Hydrogen Generation
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Editors' Series Sample Preparation Methods for Ensuring Quality Control in LC–MS-based Metabolomics
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Better Insights into Charge Variants of Therapeutic IgGs
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An Automated Software Solution for Highly Confident GC/MS Compound ID
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Increase Sensitivity and Reliability for Biopharmaceutical Applications by Simple Improvements in Sample Preparation
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Does Your Electronic Data System Meet 21 CFR Part 11 and CGMP Requirements?
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If you would like to submit an article to LCGC, contact Laura Bush, Editorial Director - LBush@mmhgroup.com
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