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LCGC North America
DECEMBER 15, 2016
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THE LCGC BLOG

HPLC Troubleshooting Tips–Poor Equilibration in Gradient HPLC

Users of liquid chromatography often face difficulties regarding irreproducibility of retention and selectivity in reversed phase HPLC. Very often, the problem lies in poor equilibration of the HPLC column between injection, which in gradient HPLC can affect the separation selectivity as well as analyte retention. Read more


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Solid-Phase Extraction for the Analysis of Drugs of Abuse in Urine

Many drugs of abuse (DOA) — whether natural or synthetic — are rapidly excreted from the human body. However, some can persist for extended periods. Screening for traces of DOAs has become commonplace by analyzing human urine with liquid chromatography–mass spectrometry (LC–MS) or gas chromatography–mass spectrometry (GC–MS) through derivitization of the parent compounds. SPE provides an ideal extraction media for DOA compounds. Download the app note.

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LCGC TV

Ionic Liquid Coatings for SPME: How Impurities Affect Performance and a Novel Polymerization Method

In the latest clip from LCGC TV, Jared Anderson from Iowa State University discusses how impurities in ionic liquids can affect the performance of SPME coatings. He also describes the novel approach for producing polymeric ionic liquid-based SPME coatings that he has developed. Read more

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Securing Your Samples with Integral Solutions

You need secure sample handling solutions throughout your analytical workflow. We provide fit-for-purpose products ensuring that samples are protected from the loss of integrity while enhancing the accuracy and reliability of data generated in your lab. We provide sample integrity and reliable data to help your laboratory thrive. Learn more


Featured News

Peak Wins UK Exporter Award

Peak Scientific has been awarded the "Best New Exporter to China Award" at the British Business Awards, held in Shanghai by the British Chamber of Commerce. Read more


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eBook: Methods for Characterizing Monoclonal Antibodies

Therapeutic monoclonal antibodies (mAbs) and their variants, such as bispecific mAbs and antibody–drug conjugates, are complex molecules that require careful characterization and quality control to ensure their safety and efficacy. This new e-book, presented jointly by LCGC and BioPharm International, provides essential information about the methods used for those purposes. Click to download

Featured Articles

GC Troubleshooting in Simple Pictures, Part II

These five pictures will help you deal with irreproducible retention times, integration issues, step-shaped peaks, poor peak shape for early eluted peaks, and loss of resolution from loss of efficiency. Read more


Workflow Development for the Analysis of Phenolic Compounds in Wine Using Liquid Chromatography Combined with Drift-Tube Ion Mobility–Mass Spectrometry

This HPLC×IMS-MS method and data analysis workflow provide a powerful and highly repeatable approach for the analysis of phenolic compounds in samples such as wine. Read more


Monoclonal Antibodies and Biosimilars—A Selection of Analytical Tools for Characterization and Comparability Assessment

This article presents a selection of state-of-the-art analytical tools for mAb characterization and comparability assessment. Read more

FEATURED PRODUCTS

MarvelX™ UHPLC Connection Systems

Advance Your Fluidics Systems with Our Expanded Portfolio of MarvelX™ UHPLC Connections. MarvelX™ UHPLC Connection Systems have been designed for easier routing throughout your instrument, with consistent performance and superior re-usability. Learn more

UCT's New PTFE-Free Sample Transfer Lines

UCT is excited to introduce our PTFE-Free Transfer Lines used in conjunction with the Glass Block Manifold. These tygon-based lines are geared towards the effective analysis of perfluorinated compounds. Learn more


NEW WEBCAST

CESI-MS for the Detection of Post-Translational Modifications (PTMs) Especially Phosphorylation Sites and Citrullination in Proteomics Research

Friday, December 16, 2016
10:30 am EST | 3:30 pm GMT | 4:30 pm CET

On Demand Webcasts

CESI-MS Detection and Quantitation of Neuropeptides


Analysis of Antibody–Drug Conjugates by Hydrophobic Interaction and Size Exclusion Chromatography: An Orthogonal Approach


Intact Proteoform Characterization Using CESI-MS

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