The LCGC Blogs

Ditch Your Mundane HPLC Methods and
Supercharge Your Chromatography

It's very easy to be comfortable with what you have. It's only when we realize what could be, that we become interested in changing things. Read more

LC-MS HIC of Large Proteins

New HIC-MS chemistries for Top Down proteomics of intact proteins. Conventional HIC materials, may not adequately retain proteins using ammonium acetate buffers, and RPC may be too hydrophobic and may denature or precipitate proteins. Our new PolyPENTYL A™ chemistry from PolyLC™ addresses this. Characterize large protein variants by HIC-MS on your MS today! The Nest Group, Inc. - “Not Just Columns ... Answers!”

The Cannabis Industry: An Analytical Chemist's Dream and Nightmare

When I want to hear some humorous stories, there are few friends in the instrument manufacturing and sales business I can contact. If I ask them about their recent experiences with the cannabis industry, their stories will cover topics ranging from instruments purchased using duffel bags of cash (cue images of large men in suits and sunglasses packing heat) to recent college graduates who cleared $25 million in their first year of business selling cannabis butter (cue images of large men at breakfast laughing uncontrollably). Read more

LCGC TV

A Microfluidic Device for 3D LC

Peter Schoenmakers from the University of Amsterdam talks through his group's designs for a microfluidic device for 3D LC and the challenges that had to be overcome. Read more

Featured Articles

Advancing Food Analysis with Ultrahigh-
Pressure Liquid Chromatography and High-
Resolution Mass Spectrometry

In food analysis, HPLC and triple-quadrupole mass spectrometry are established techniques. Jon Wong of the Center for Food Safety and Applied Nutrition at the U.S. Food and Drug Administration discusses why his agency and others have been developing food analysis methods using UHPLC and HRMS. Read more

Static Mixers For Better Gradient Sensitivity

Are you looking for up to 80% reduction in baseline noise using mobile phases like TFA and Formic Acid? Lack of proper mixing could be the cause of ripples in your HPLC chromatographic results. Download our whitepaper on Mott PerfectPeak^® In-Line Static Mixers. Better mixing, better resolution, better peaks.
Learn more

Using Benzoyl Chloride Derivatization to Improve Small-Molecule Analysis in Biological Samples by LC–MS/MS

In metabolomics, LC–MS is a popular technique because of its ability to separate a wide range of metabolites, but the presence of many highly polar analytes in these samples poses a challenge. Benzoyl chloride derivatization can be a practical solution, improving both sensitivity and selectivity. Read more