| Technology Forum |
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Thin-Layer Chromatography
Thin-layer chromatography (TLC) provides analysts with a simple and quick method for examining the components in a mixture, and advances in the technique such as high performance TLC (HPTLC) offer higher resolution and greater reproducibility. Joining us for a discussion on TLC this month are Ned Dugan of Analtech, Inc., and Ling Bei and Dave Lentz of EMD Chemicals.
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No Matter What Your Purification Scale, Waters has Your Solution
The new Charged Surface Hybrid (CSH) prep columns offer the greatest benefits to purification scientists including fast screening using ACQUITY UPLC CSH columns that can be directly scaled to XSelect Prep Columns. These preparative columns, offered in Optimum Bed Density Technology (OBD), will provide:
· high loadability of bases using simple low or high pH mobile phases
· long, predictable column lifetimes
· widest selectivity range in CSH C18, CSH Fluoro-Phenyl, CSH Phenyl-Hexyl stationary phases
 Find out more.
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| Featured Articles |
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Are the Method Requirements Reasonable?
If something doesn't look right you need to investigate!
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Finding the Best Separation for Enantiomeric Mixtures
The authors describe a study of screening procedures that demonstrated a relatively small set of columns can be used routinely.
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Unrivalled Cleanliness:
With highly sensitive chromatography applicationsrequiring complete elimination of any potentially contaminating substances, it is vitally important that you can be sure that all equipment used is clean, with a high level of purity. National Scientific Mass Spec Vials are pre-cleaned and tested as standard to provide you with an extra level of assurance.
To get your free sample pack, visit  www.nationalscientific.com/mscertified now! |
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| Featured Application Note |
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Complementary Selectivities of Kinetex® Core-Shell Phases: C18, XB-C18, C8 and PFP
Further research and product development of Kinetex core-shell media has culminated with the introduction of two additional bonded phases, Kinetex XB-C18 and Kinetex C8. These new phases offer complementary selectivities to the existing Kinetex phases (C18, PFP, and HILIC) giving chromatographers additional solutions for their ultra-high performance separations, especially useful for basic compounds and for LC-MS conditions.
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Effect of Temperature on Elution Order in GC
When analyzing via GC, the desired separation can sometimes be achieved by changing the oven program. This technique takes two properties into account: a compound’s boiling point and its ability to interact with the stationary phase.
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Fast and easy GC pressure and flow calculations…anywhere, anytime
Agilent has created the first-of-its-kind gas chromatography app for the iPhone and iPod touch. The GC pressure and flow calculator app can instantly and accurately determine pressures and flows through open tubular capillary columns. The app is based on the popular PC version that has been downloaded more than 10,000 times from the Agilent website.
To learn more and download:  www.agilent.com/chem/gcapp
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Featured Products
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No Matter What Your Purification Scale, Waters has Your Solution
Waters is the laboratory technology leader that first brought mass-directed purification to the commercial market, and Waters is once again first to bring a single-vendor solution that encompasses the entire purification range. From HPLC to the newest SFC innovations, to world-class service and worldwide support, you can depend on Waters for all of your purification needs.  waters.com/prep
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ALEXYS Clinical & Diagnostic Analyzer
Routine analysis of catecholamines, serotonin in urine or plasma, metabolites e.g., metanephrines, VMA, HVA, 5-HIAA in urine, etc., Antec provides fast, accurate and proven application fluidly running on its ALEXYS™ Analyzers.  Read more... |
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Visit Tosoh Bioscience at EAS booth 219
Inquire about our new TSK-GEL® columns. TSK-GEL SuperMultiporePW GPC columns are packed with particles that contain a broad range of pore sizes for the analysis of water-soluble polymers. For the determination of molecular mass of aqueous oligomers, particularly oligosaccharides, and low molecular weight aqueous polymers, a TSKgel® SuperOligoPW GPC column is now available.
TSK-GEL NH2-100 DC columns are for the simultaneous separation of APIs and counterions.
 Read more...
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Market Profile
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Dissolution Testing
Dissolution testing is a mandatory test for the physical evaluation of solid dosage forms, such as capsules, tablets, ointments, and creams.
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OpenLAB unlocks your lab's full potential
Nov. 15-16, Special Mini-Symposium at AAPS/PSWC plus Educational Seminars
In your quest to increase sensitivity, improve throughput, and explore new techniques in bioanalysis, look to Waters as a partner. We develop the best LC/MS/MS technologies for assay sensitivity and quality, and partner with industry leaders to advance applications such as 2D separations, microfluidics-MS/MS, dried blood spot analysis, and sample cleanup and concentration strategies.
 Read more...
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Ask LCGC
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GC System Maintenance |
| Q: |
What are the basic elements of preventative maintenance for a GC system? |
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| A: |
Preventative maintenance includes replacing consumable items and performing maintenance procedures on a regular basis. Important periodic maintenance includes the following items…
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CHROMmunity
A service by LCGC and CHROMacademy |
Forum and Networking site for Chromatographers. |
Join in the Big Chromatography Conversation. Free Registration.» |
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Featured Webcasts & Podcasts |
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Increase LC–MS Throughput and Improve ROI for Biological Samples— On Demand
We will present a case study based on this strategy as a tool to analyze 45 drugs of abuse in performance horses.
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LC and LC–MS in the Pharmaceutical Industry: Small Molecule Quantitative Analysis and Matrix Effects— On Demand
Dr. Kevin A. Schug, Assistant Professor at the University of Texas at Arlington will discuss fundamental and applied studies of LC and LC–MS for trace quantitative analysis of small molecules and metabolites.
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Supercritical Fluid Chromatography in Theory and Practice
In this podcast series, we’ll be discussing how users can benefit from supercritical fluid chromatography (SFC) in their laboratories.
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Optimizing Chromatographic Conditions for Protein Analysis with the ACQUITY UPLC H-Class Bio System
Biopharmaceutical proteins are large, complicated molecules and demand multiple modes of analysis to ensure complete characterization of the sample.
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Upcoming Events |
14–18 November 2010
Pharmaceutical Sciences World Congress 2010
New Orleans, LA.
» Visit the website
15–17 November 2010
Eastern Analytical Symposium and Exposition (EAS)
Somerset, NJ.
» Visit the website
30 November–4 December 2010
ACS 66th SWRM (Southwest Regional Meeting) and 62nd SERMACS (Southeast Regional Meeting)
New Orleans, LA.
» Visit the website
15–20 December 2010
Pacifichem 2010- The Int. Chemical Congress of Pacific Basin Societies
Wichita, KS.
Honolulu, HI.
» Visit the website
19–21 January 2011
IFPAC 2011: 25th International Forum Process Analytical Technology
Baltimore, MD.
» Visit the website
13–18 March 2011
Pittcon 2011: The Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy
Atlanta, GA.
» Visit the website
29–31 March 2011
INTERPHEX 2011
New York, NY.
» Visit the website
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