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LCGC North America
SEPTEMBER 15, 2016
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The LCGC Blog

Getting the Most from Phenyl Stationary Phases for HPLC

I've often written about the "lazy" chromatography which has swept through our industry, whereby 0.1% (w/w or w/v!) TFA or formic acid is used to "buffer" the eluent system well away from the pKa of analyte molecules, leaving most acidic analytes in the ion suppressed form and most basic analytes in the ionized form. This approach avoids having issues with retention time drift and effectively eliminates pH as a variable used to control retention or selectivity for separations involving ionogenic analytes. Read more



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Webinar on High Throughput PFC analysis
The TurboTrace® PFC (Perfluoralkylated substances) SPE system is designed to streamline your laboratory's workflow and increase productivity by automating the manual steps in your sample preparation process. It is designed for high throughput and tough sample matrices. It is the first automated solid phase extraction system made specifically for PFC extraction and concentration. Effective at reducing background contamination, extraction and concentration of aqueous samples takes less than two hours.
Register for the Webinar on October 12th


LCGC TV

Analyzing Oil Spills: The Impact Over Time

Understanding the impact of an oil spill on the environment is vital to managing it. In the latest clip from LCGC TV, Alan G. Marshall from the National High Magnetic Field Laboratory at Florida State University discusses how FT-ICR-MS offers insights into what is happening in the Deepwater Horizon oil spill.
Read more

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Say goodbye to loud, oil-sealed GC pumps
The Agilent IDP-3 dry scroll pump puts distracting noises, oily messes, and pump seizures behind you once and for all. It features Oil-free operation that minimizes pump failures, Environmental friendliness as there is no more oil Leaks/spills, Powerful vacuum performance and last but not least, lightweight with low noise and minimal power requirements. www.agilent.com/chem/idp3


Featured Articles

HPLC Column Standardization in Pharmaceutical Development: A Case Study

How one organization encouraged its staff to develop HPLC methods using fewer column brands and dimensions to reduce waste
Read more


Retention Time Prediction Based on Molecular Structure in Pharmaceutical Method Development: A Perspective

Can chromatographic method development be streamlined? Read more

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Zip-Vap® Evaporators
Our Zip-Vap® line of evaporator are a low cost solution for the removal of solvent and water. Ideal for auto-sample vials to 250ml bottles. Heated systems available to 100°C for increased evaporation rates.
Learn more


Featured Video

Breakthrough GC Innovation: Polyarc® System

The Polyarc® system enhances GC/FIDs by converting all organic compounds to methane molecules for universal carbon detection. It's easy to use and seamlessly integrates into new or existing GCs, providing better data quality, increased throughput and more economical operation. View the video here

Quick Poll

UHPLC Pressure

When you work in UHPLC, what pressure do you actually use? Let us know by taking our quick poll! Results will be shared in an upcoming print issue of LCGC.
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FPLC versus Analytical HPLC: Two Methods, One Origin, Many Differences

Fast protein liquid chromatography (FPLC) and high performance liquid chromatography (HPLC): two liquid chromatographic methods in direct comparison. This article discusses the differences between the two techniques with particular emphasis on the requirements of their respective analytes.
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Phosphorylated Peptide Isolation Improvement
New! The ERLIC-WAX chemistry, in both column and microSPE formats, addresses multi-phosphorylated peptide isolation challenges better than titania methods. Then desalting byTARGA® C18, UltraMicroSpin™ SPE from 100% water can improve recovery of these polar molecules prior to LCMS.Try one of our ERLIC WAX & TARGA separation approaches today! The Nest Group, Inc. - "Not Just Columns ... Answers!"


Featured Products

MarvelX™ UHPLC Connection Systems

Advance Your Fluidics Systems with Our Expanded Portfolio of MarvelX™ UHPLC Connections. MarvelX™ UHPLC Connection Systems have been designed for easier routing throughout your instrument, with consistent performance and superior re-usability.
Learn more

UHPLC columns speed at highest performance

Purospher® STAR RP-18 endcapped UHPLC columns packed with 2 µm silica sorbent can decrease separation time by a factor of 10 and reduce solvent consumption by up to 90%.
Learn more

ACD/AutoChrom—Automated Method Development

Apply QbD principles, eliminate errors, increase experimental scope, retain knowledge:
• Instrument control for Agilent and Waters systems
• Comprehensive method screening
• Single and multivariate parameter optimization
• Automated peak tracking run-to-run
Learn more

Metrohm IC Products Controlled by Waters Empower Software

Metrohm ICs now integrate with Empower to simplify the validation process and minimize training needs. With only minimal changes to SOPs and workflows, you can now enjoy the great features of Metrohm ICs in your familiar CDS. Learn more

Celebrate 40 years of Thermo Scientific™ Hypersil™ with us

Celebrate 40 years of Thermo Scientific™ Hypersil™ and receive a complimentary Hypersil column pen*. Thermo Scientific™ Hypersil delivers innovative separation solutions to achieve better and faster results, that enable our customers to make the world healthier, cleaner and safer. Register now
*Terms and Conditions Apply

UCT's New Glyphosate Purification Cartridges

Small and large push-thru glyphosate purification cartridges allow aqueous extracts to pass through a small or large filter cartridge to remove organic material and surfactants for the chromatographic analysis of glyphosate and glufosinate. Try out a sample today!

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E-Book: Quantitation of Biopharmaceuticals & Pharmaceuticals by Mass Spectrometry
The quantitation of proteins in complex biological samples is an important and challenging task. Quantitation of small-molecules, while less challenging, also requires some special considerations. This new e-book presents essential information about these analyses, from general precepts through specific considerations when developing an LC–MS–MS method. Download your e-Book


NEW WEBCASTS

What Does the Future Hold for Ambient Air Monitoring Regulations? A PAMS site instrumentation for VOCs monitoring

Wednesday, September 28, 2016
8 am PDT | 11 am EDT | 4 pm BST | 5 pm CEST


ON DEMAND WEBCASTS

Using the X500R QTOF with SWATH Acquisition for Confident Contaminant (PFAS), Flavor, and Color Analysis: Screen, Quantify, & Identify Unknowns


Analytical Workflow Tools for Monoclonal Antibody Development and Characterization


Extreme-Throughput, Comprehensive Gas and Headspace Analysis: Automated SIFT-MS



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