The LCGC Blog
Let's first properly define carryover in the context that I’d like to discuss here. An injection is made and a chromatogram obtained. On injecting a "blank" as the next injection, one or more of the components of the previous s injection appear in the "blank" chromatogram. Read more
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New EXP UHPLC guard column cartridges are made specifically for Raptor 1.8 µm columns. They provide extreme protection from particulates and matrix contamination, extend the lifetime of already rugged and long-lasting Raptor columns, and are proven to withstand the same UHPLC pressures as their analytical column counterparts. These new guard column cartridges are especially valuable when using dilute-and-shoot or other minimal sample preparation techniques.  Learn more
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Featured Articles
Blanks are important in the pursuits of quality control and robust quantitative analytical methods, but many analysts don't fully understand their value, or how to use them correctly. Read more
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The International Symposium on High Performance Liquid Phase Separations and Related Techniques (HPLC) is one of the most high-profile events for chromatographers. The organizers of this year's event, HPLC 2018, have collaborated with the LCGC editorial team to share some highlights from this year's event through this ebook, which brings you interviews with several keynote speakers.  Click here to download
A new type of analysis called "wide-selected ion monitoring (SIM)/MS2" scanning, is capable of screening for a wide range of DNA adducts (chemical modifications to genomic DNA). This method has successfully identified DNA adducts from carcinogen exposures and oxidative stress in human prostate and kidney tissues. Read more
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The molecular complexity of monoclonal antibodies (mAbs) makes accurate characterization challenging. This ebook highlights versatile and automated mass spectrometry-based approaches for intact protein analysis, peptide mapping, and glycan analysis that deliver quick and reliable answers.  Download the eBook
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More Featured Articles
These ten propositions are widely acknowledged, but frequently neglected, by practitioners of high performance liquid chromatography.
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We explore the developments that have made it possible to produce sub-minute, and, more recently, even sub-second enantiomeric separations. We also look at the questions that remain unanswered. Read more
A storm of three letter acronyms (TLAs) is on the way, which is set to radically update the way in which analytical methods are developed, validated, and verified, and the pharmacopeial bodies and regulators are at the heart of the storm. Read more
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Application Note
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UCT's CLEAN UP® CCX extraction columns along with a Selectra® PFPP HPLC column allowed for excellent sample clean up and analyte separation.
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FEATURED PRODUCTS
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Specially calibrated for trace sample isolation, the Magnum Syringe’s twist-lock valve seals the sample inside the syringe to maintain its integrity during transportation to the analysis site.  / Read more / |
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The Eclipse® DualTec™ system offers both Hollow-Fiber Flow-FFF (HF5) and Asymmetric Flow-FFF (AF4) techniques. Both may be integrated into one instrument and coupled seamlessly to the most advanced light scattering detector for determination of molar mass and nanoparticle size, Wyatt's DAWN® HELEOS® II.  / Read more / |
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Postnova presents an innovative new simultaneous Electrical and Asymmetrical Flow Field-Flow Fractionation (EAF4) system designed to enhance separation and characterization of biopharmaceutical, environmental and nanomaterials. In an EAF2000 system Electrical and Cross Flow Fields are applied simultaneously enabling separations by particle size and particle charge based on electrophoretic mobility for characterizing complex proteins, antibodies and viruses as well as environmental and charged nanoparticles or polymers.  Learn more |
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PerfectPeak® Flow Splitters give better peak resolution and accurate splitting with easy to install finger-tight fittings. This splitter allows for extremely low internal volume resulting in minimal dispersion for better data.  / Read more / |
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b-cyclodextrin based chiral stationary phase bonded with state-of-the-art superficially
porous particles serve as a leading chiral column for pesticide applications using sensitive
mass spectrometry detection (fungicides, insecticides, rodenticides, herbicides, etc.).
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Low-cost Fixed Wavelength Filter Detector is excellent for monitoring HPLC and Low Pressure or Flash Columns. Preparative or Analytical Flowcells. Wavelengths available (214, 230, 254 280nm and more). OEM configurations available.  Learn more |
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