The LCGC Blog

A Weighty Problem with Calibration

Chromatographic methods often require that the analyte response is calibrated (and validated) over a wide concentration range when the analyte concentration in the sample is either unknown or is expected to vary widely. Bioanalysis, environmental, and clinical applications are just a few examples of where this may be the case. Read more

A Guide to Finding the Ideal HPLC Column

• HPLC 101 provides definitions and terminology
• Answers to common questions when starting your column selection process
• "How-To" page helps you choose a product that's right for your application
• Care and Storage section advises on maximizing the life of your product
• Technical References include resin specifications and useful chromatography calculations

Download our Hamilton HPLC Columns Reference Guide today!

When Do We Need Sub-2-μm Superficially Porous Particles for Liquid Chromatography Separations?

Many manufacturers now offer columns using superficially porous particles that are 2-µm and smaller. When should you use them? Read more

Siderophore Biometal HILIC Separations

iHILIC® Fusion column separations assisted identification of 4 new structures for this Siderophore (Biometal) class of high-affinity, iron-chelating compounds which transport iron across cell membranes. Try our iHILIC® Fusion chemistry today for your most demanding HILIC applications. Tested and proven by leading metabolomics laboratories. The Nest Group, Inc. - "Not Just Columns … Answers!" Learn more

Featured Articles

Split, Splitless, and Beyond—Getting the Most from Your Inlet

We discuss the challenges of split and splitless injections, ideas for mitigating them, and the case for renewed exploration of cool inlets and injection techniques. Read more

mAb/ADC Analysis: New Bio-Inert Hardware and bioZen LC Column Portfolio

This LCGC ebook takes an in-depth look at how a new column technology helps save time and resources during protein analysis. Download the eBook

Data Integrity in the GXP Chromatography Laboratory, Part IV: Calculation of the Reportable Results

You need to ensure that your calculations of reportable results don't get you into data integrity trouble. Here's how. Read more

Biopharma Resource Center

We've gathered some essential biopharma information designed for your field and labs. Download the compendium, poster, application note, and more. Click here to access the Resource Center. Click here to access the Resource Center.