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JULY 6, 2017
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The LCGC Blog

Intact Protein Ion Transmission in a Triple-Quadrupole Mass Spectrometer

Protein quantitation using top-down strategies, especially on low-resolution triple-quadrupole systems, have been largely ignored, until recently. Read more


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SPE System for Perfluorinated Compounds in Water

PFOS and other perfluorinated compounds are widely used in industrial and consumer applications including stain-resistant coatings for textiles, leather, and carpets, grease-proof coatings for paper products approved for food contact, firefighting foams, mining and oil well surfactants, floor polishes, and insecticide formulations. In recent years, there has been increasing concern over the levels of perfluorinated and polyfluorinated chemicals. Learn More About Automated PFC Extraction.

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Featured Articles

Critical Evaluation of HPLC Methods: Working with Ionizable Analytes

Improve your analysis of ionizable analytes with these hints and tips. Read more


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BioPureSPN™ Midi SPE

New! Semi-Reusable, BioPureSPN™ Midi RPC spin columns with 20% more packing are 100% more reliable. Improve recovery prior to LC-MS from desalting of glycans, nucleotides, peptides, etc. with this enhanced bed of the PROTO™ 300 or TARGA® chemistry. Try our color-coded BioPureSPN C18 spin columns or cartridges today! The Nest Group, Inc. - "Not Just Columns ... Answers!"


Mitigating the Effect of Surfactants in Sample Preparation of a Phospholipid Formulation for Impurities Analysis by Reversed-Phase Liquid Chromatography

When a formulation change reduced the drug load sixfold, a new sample preparation approach was needed to ensure a robust method. Read more


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Register today for the International Symposium on GPC/SEC and Related Techniques taking place October 2nd-5th in New Orleans, Louisiana, USA. Come learn about the latest innovations in polymer characterization from leading experts at Dow, DuPont, Arkema, DSM Resolve, and more. Don't miss this opportunity to discuss novel solutions that address current analytical challenges facing the polymer characterization industry. Learn more at www.gpcevent.com.


LCGC TV

Where Does Green Chemistry Stand Today?

Susan Olesik from The Ohio State University talks about the role of green chemistry in industry and how the movement is very much alive and well. Read more


More Featured Articles

Evaluation of Retention and Selectivity Using Biphenyl Stationary Phases

In biphenyl phases, the surface chemistry often makes it possible to separate compounds not well resolved by C18 or phenyl phases. Read more


Analysis of Organic Compounds in Water Using Unique Concentration–Injection Techniques for Portable GC–MS

In this study, a simple method was used for extraction and concentration of trace organic compounds in water, followed by injection using a coiled wire filament and GC–MS analysis. Common semivolatile organic compound contaminants at low parts-per-billion levels were detected in less than 10 min. Read more

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Three Proprietary HILIC Selectivities

Advanced Chromatography Technologies have introduced three exciting new selectivities for HILIC. These novel proprietary phases have been developed to enable chromatographers to achieve reproducible, successful HILIC separations. Learn more

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Application Notes

Proof of Equivalency for the Analysis of Local Anesthetics

This application note proves equivalency of the Agilent 1200 Series Binary LC and the Agilent 1260 Infinity II LC for the analysis of local anesthetics. read more

Transfer the USP Method for Ceftizoxime within Chapter 621 Guidelines

A traditional method of USP assay of ceftizoxime using a 5-µm column can be successfully transferred to a superficial porous column. read more


New Webcasts

Webinar 1: Getting the Most out of Your LC Systems

Tuesday, July 11, 2017
11 am EDT | 8 am BST | 4 pm BST | 5 pm CEST
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Orbitrap GC-MS: An Opportunity to Help Address the Challenges of Chlorinated Paraffins Analysis

Wednesday, July 12, 2017
11 am EDT | 8 am PDT | 4 pm BST | 5 pm CEST
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Complete Structural Insight into Therapeutic Proteins: Using Mass Spectrometry Under Native & Denaturing Conditions
Part II: From Optimized Sample Preparation to Data Analysis: LC-MS Analysis of Therapeutic Proteins on the Intact and Subunit Level

Thursday, July 13, 2017
11 am EDT | 8 am PDT | 4 am BST | 5 am CEST
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Low Energy, High Confidence: Eliminating Unknowns with GC/Q-TOF

Thursday, July 13, 2017
11 am EDT | 8 am PDT | 4 pm BST | 5 pm CEST
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Analysis of Residual Solvents in Pharmaceutical Excipients and Products by GC-VUV – Reduction of GC runtimes by greater than 5x – Ability to combine different solvent classes into a single run

Tuesday, July 18, 2017
11 am EDT | 8 am PDT | 4 pm BST | 5 pm CEST
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Orthogonal Chromatographic Techniques for the Quantitative Analysis of Potential Mutagenic Impurities

Wednesday, July 19, 2017
10 am EDT | 9 am CDT | 3 pm BST | 4 pm CEST
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Rapid Volatile Impurity Analysis in Pharmaceutical Products Using SIFT-MS

North America Broadcast: Wednesday, August 16, 2017
11 am EDT | 10 am CDT | 8 pm PDT

Europe Broadcast: Wednesday, August 16, 2017
2 pm BST | 3 pm CEST
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Webinar 2: Taking Advantage of LC Column Characteristics to Improve Analyses

Wednesday, August 30, 2017
11 am EDT | 8 am PDT | 4 pm BST | 5 pm CEST
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Webinar 3: Making Good Methods Even Better

Tuesday, September 19, 2017
11 am EDT | 8 am PDT | 4 pm BST | 5 pm CEST
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On Demand Webcasts

The Application of Spectral Accuracy to Mass Spectrometry for Enhanced Formula ID and Mixture Analysis


Using Magnetic Sector GC–HRMS in a Commercial Dioxin Lab


Who Cares about SVOCs? The Next Generation of Product Emission Testing for Indoor Exposure Modeling


Editors' Series: Combining Non-Target and Target Screening of DBPs: Assessing Removal Strategies to Make Drinking Water Safer


How to Understand Measurement Uncertainty in TOF Mass Spectrometry and Ion Mobility-Mass Spectrometry

Monoclonal Antibody (mAb) Characterization: Purity, Charge Heterogeneity and Glycan Analysis on a Single Platform Technology


Shortening Biosimilar Development: A Case Study Integrating Early Clinical (Phase I) with late phase (Phase III) Biosimilars Development


Complete Structural Insight into Therapeutic Proteins: Using Mass Spectrometry Under Native & Denaturing Conditions
Part I: Simplified Mass Spectral Characterization of Complex Biotherapeutic Drugs Under Native and Denaturing Conditions


Evolution of Liquid Chromatography Triple-Quadrupole Mass Spectrometry for Low-Level Residue Analyses in Food and Environmental Matrices: Ultivo, the Next Generation of "Fit for Purpose" LC/TQ

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