We are frequently asked about issues with reduced peak size in gas chromatography (GC), and I’m guessing this is related to just how difficult this problem is to troubleshoot. Fear not. What follows is our logical guide to locating and fixing the issues with loss of sensitivity, and we’ve tried to cover as many of the instrument and application issues that we can think of. Learn more
For this brief piece we have elected to focus on three aspects of recent work by the 2D-LC community that we think are especially noteworthy: 1) Movement toward “generic” 2D-LC methods; 2) development of ultrahigh peak capacity methods; and 3) solutions that address the “solvent mismatch” problem in 2D-LC.
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We explore what’s new in the liquid chromatography columns and accessories commercially released over the past year.
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Advancing your IC science–45 years strong For 45 years, Thermo Scientific™ Dionex™ ion chromatography solutions have developed reliable, reproducible analyses for people just like you. As you pursue bold new ideas, we’re here to support you now and into the future. With us as your partner, you’re connected to best-in-class IC separation solutions to help you achieve new discoveries. Be bold, we’re on your side. Learn more
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When working with complex samples, we need effective approaches to deal with matrix interferences. Here, we outline methods of sample preparation, on-line sample treatment, and instrument tools that can help. We also provide examples of applications and guidance for how to evaluate the best option for your complex sample.
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Water-soluble macromolecules require water as a mobile phase, and method development therefore seems to be straightforward. At second glance, however, aqueous gel permeation chromatography/size-exclusion chromatography (GPC/SEC) is complex and the choice of the stationary phase and pH are crucial. In addition, mobile phase additives are often required to allow for interaction-free separations.
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The Column spoke to Evelien Dejaegere from Waters Corporation about the method life cycle management approach and its importance in the pharmaceutical sector.
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Pro EZLC method translation software makes it quick and easy to scale down an existing LC method to a smaller column format so you can speed up run time, increase sample throughput, and reduce solvent use. / Learn More /
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Check out Hamilton’s online HPLC Application Index today!
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