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LCGC North America
FEBRUARY 14, 2019
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The LCGC Blog

HPLC Diagnostic Skills–Noisy Baselines

Just as medical practitioners are able to discern worrying features from a variety of medical physics devices (electrocardiogram, electroencephalogram, ultrasound, for example), we need to develop the skill to identify worrying symptoms from our HPLC instrument output. Learn more


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A Guide to Finding the Ideal HPLC Column

  •   HPLC 101 provides definitions and terminology
  •   Answers to common questions when starting your column selection process
  •   "How-To" page helps you choose a product that's right for your application
  •   Care and Storage section advises on maximizing the life of your product
  •   Technical References include resin specifications and useful chromatography calculations
Download our Hamilton HPLC Columns Reference Guide today!


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Featured Articles

Is Headspace Sampling Quantitative?

Whether or not headspace sampling is quantitative depends on the information gleaned from the analysis. Learn more


Methods and Purposes for Determining Higher Order Structures of Biopharmaceuticals

Determining the higher order structure of a protein pharmaceutical is important. Here, we review the approaches for HOS determination that are currently receiving the most attention in the literature and at scientific meetings. Learn more


Drawing A Better Map: Recent Advances in Protein Digestion and Peptide Mapping

New strategies for "bottom-up" analysis of therapeutic proteins, using faster enzymes, new buffer systems, and optimal column chemistries, enable analysts to perform these studies much faster and with fewer artifacts. Learn more


Development of a Multi-Product SE-UHPLC Method for the Determination of Size-Variants in Bispecific Antibody Formats

The versatile size-exclusion ultrahigh-performance liquid chromatography (SE-UHPLC) platform method described here provides superior separation for bispecific monoclonal antibody formats compared to a previous method. Learn more


Stopping GC and GC–MS Problems Before They Start

By taking simple proactive troubleshooting steps, GC users can ensure that instruments will operate correctly over time, thus avoiding workflow disruptions. Learn more


FEATURED WHITEPAPER

Characterization of non-compendial impurity reference standards

Are you aware of the risks involved in using a quantitative reference standard designed for qualitative use only? Learn about characterization of reference standards. / Read more /


FEATURED PRODUCTS

VICI Precision Sampling Mininert Valves

VICI Precision Sampling Mininert valves are the ideal closure for calibration standards, air or moisture sensitive fluids, derivatizing reagents, and volatile chemicals. Easy push-button valves make highly dependable leak-tight closures for screw-cap vials and other laboratory containers. / Learn more /

UV-Vis Variable Wavelength Absorbance Detector

DVW-10 Variable Wavelength Detector is excellent for monitoring HPLC and Low Pressure or Flash Columns. Preparative or Analytical Flowcells. Wavelength (185 to 800nm). OEM configurations available. / For more information click here /

TOF Analytical Instruments

GenTech Scientific has many instruments in stock and ready for your lab. Our available TOF instruments will provide you the resolution and stability needed at a fraction of the cost of new. / Read more /

µPAC™ Trapping column

PharmaFluidics launches µPAC™ Trapping columns to support their analytical columns. These micromachined trapping columns were developed with identical stationary phase morphology as the analytical columns to ensure optimal chromatographic performance. / Read more /


UPCOMING WEBCASTS

Improvement of Both Legacy and New HPLC Methods with Superficially Porous Particle Columns

Wednesday, Feb. 20, 2019 at 1 pm EST | 12 pm CST | 10 am PST
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Extraction of Pesticides from Difficult Food Matrices

Thursday, Feb. 21, 2019 at 11 am EST | 8 am PST | 4 pm GMT | 5 pm CET
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The Importance of Computer System Validation for Regulated Systems

Europe: Tuesday, Feb. 26, 2019 at 2 pm GMT | 3 pm CET
North America: Tuesday Feb. 26, 2019 at 2 pm EST | 1 pm CST | 11 am PST
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Native Mode Mass Spectrometry Analysis

Wednesday, Feb. 27, 2019 at 11am EST | 8am PST | 4pm GMT | 5pm CET
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Achieving PEEK-like Performance on Stainless Steel HPLC Components with Bio-Inert CVD Coatings

Europe: Thursday, Feb. 28, 2019 at 11 am EST | 8 am PST | 4 pm GMT | 5 pm CET
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ON DEMAND WEBCASTS

Optimizing SEC for Analysis of Antibodies and Antibody–Drug Conjugates


Probing Submicron Protein Aggregation Using Asymmetrical Flow Field-Flow Fractionation (AF4) and Light Scattering


Moving to the Cloud: Key Considerations


Leveraging Exception Reporting to Optimize Chromatography Data Review



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