Selectivity changes can range from subtle shifts in relative retention of a single peak within the chromatogram to wholescale retention order swapping of every peak, and we need to be able to spot these changes and investigate the causes in a systematic and proficient manner. However, with so many variables effecting selectivity, it is sometimes difficult to know where to begin our diagnostic investigations. Learn more
We return to the important topic of buffers, this time focusing on what happens when there is a mismatch between the mobile-phase buffer pH and the pH that the sample is buffered at.
Learn more
Long-term column use can lead to on-column methionine oxidation during LC–MS/MS peptide mapping of antibody-based biotherapeutics. Following the approach described here minimizes the risk of measuring oxidative artifacts, and helps generate high quality data to provide reliable quantitative information about product-related heterogeneities.
Learn more
advertisement
Do More with Your Data. There’s no limit to what you can achieve with a reimagined digital strategy. LabVantage Solutions helps with a modern, expanding informatics platform and professional services that deliver powerful, problem-solving solutions to your greatest data challenges. Learn how LabVantage has helped organizations like yours achieve digital transformations to gain a competitive advantage. Visit us at Pittcon, booth 4432, to see our all-new SDMS.
Advanced separation and mass spectrometry methods enable comprehensive profiling of the inherent glycan heterogeneities of protein therapeutics. In particular, reversed-phase HPLC–based multiattribute methods (MAMs) provide a wealth of information, and other techniques, such as HILIC and CE-MS, also continue to evolve.
Learn more
Aogu Furusho from the Graduate School of Pharmaceutical Sciences in Kyushu University, Fukuoka, Japan, spoke to us about his development of a highly selective three-dimensional chiral high performance liquid chromatography (HPLC) system for the determination of extraterrestrial amino acids in carbonaceous chondrites.
Learn more
A simple and robust size-exclusion chromatography (SEC) method has been developed for characterizing a multimeric PEG–protein conjugate. A wide range of size variants of the conjugate, ranging from 50 kDa to >1000 kDa, can be resolved and quantitated.
Learn more
The highest performance LC/TQ available with Agilent's third generation iFunnel design, ideally suited for peptide quant as well as multiresidue applications that require ppt sensitivity. The combination of utmost sensitivity, extended mass range, ease of maintenance with VacShield technology, and the power and flexibility of MassHunter makes this the system of choice for demanding applications./ Learn More /
Our wide-mouth volumetric flask is everything you need to prep your chromatography vial. Available from DWK Life Sciences for a limited time at up to 70% off! For volumetric precision, we are the standard./ Learn more /
Throughput, robustness and reproducibility are key-features of the new µPAC™ capLC columns. With its unique micro-pillar array backbone, flow rates of 1-15 µL/min allow for high throughput and sensitive analysis. / Learn more /
The Postnova EAF2000 instrument using Electrical Asymmetrical Flow Field-Flow Fractionation (EAF4) technology allows the particle size or molar mass distributions to be further differentiated and transformed into charge distributions. /Learn more/
With a variety of Smart features, easy maintenance, and intuitive software, Shimadzu’s GCMS instruments provide more efficient workflows, greater uptime, and reduced costs for higher productivity and better ROI. / Learn more /
SilcoTek’s bio-inert CVD coating, Dursan, is changing the game in HPLC. This versatile coating improves corrosion resistance, testing reliability, and part lifetime. Replace PEEK and expensive alloys with Dursan-coated stainless steel. / Learn more /
Europe: Thursday, Mar. 5, 2020 at 2 pm GMT | 3 pm CET
US: Thursday, Mar. 5, 2020 at 1 pm EST | 12 pm CST | 10 am PST
Asia Pacific: Friday, Mar. 6, 2020 at 9:30am IST | 12pm CST | 1pm JST
Register>>
Visit us at Pittcon, booth 4432, to see our all-new SDMS.
/ Learn More /
/ Learn more /
/ Learn more /
/Learn more/
/ Learn more /
/ Learn more /