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LCGC North America
February 8, 2018
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The LCGC Blog

Screening Platforms for HPLC Method Development

I'm often asked to help with the development of column "screening" platforms and automated development systems. While this covers a large amount of analytical science there are some common elements to this type of approach, perhaps the most important of which is column selection. Unsurprising given that "selectivity" is the most powerful tool we have in chromatography and we all know that the best way to optimize selectivity is to choose the most appropriate stationary phase. Read more


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Focus on Results. Uninterrupted.

What if your ion chromatography system could operate without taking a break? Discover how capillary ion chromatography can keep your laboratory running 24/7 while reducing eluent waste and disposal costs. Learn More


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Featured Articles

A Look at Matrix Effects

In the environmental analytical chemistry literature, the topic of matrix interferences and matrix effects has not been addressed in a fundamental way. Here, we examine which methods appear to have a tendency for matrix interference and suggest ways to reduce the problem. Read more


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7th International Symposium

Join CASSS for the 7th International Symposium on Higher Order Structure of Protein Therapeutics taking place on April 9-11, 2018 in Providence, Rhode Island. HOS 2018 will include informative presentations by industry experts, interactive discussions, and networking opportunities. Learn more and register now!


Peak Shapes and Their Measurements: The Need and the Concept Behind Total Peak Shape Analysis

A number of approaches for peak shape measurement are available in modern chromatography software. We discuss the advantages and drawbacks of those approaches, and present a new concept, "total peak shape analysis." Read more


Tips for Troubleshooting Liquid–Liquid Extractions

A common challenge in LLE is the formation of emulsions. Several approaches can address the problem. Or, one can try an alternative technique. Read more


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The Proton OnSite Hydrogen Lab Server

The Proton OnSite Hydrogen Lab Server produces up to 18.8 SLPM of ultra-high purity hydrogen gas sensing demand and adjusting production accordingly. When installed into a gas system, it can serve numerous floors and rooms with a constant, pure stream of hydrogen gas. This compact generator produces the equivalent of four cylinders of hydrogen every day – eliminating the cost and hazards associated with delivered gas. Learn more


Tips and Tricks for New Gas Chromatographers

Three main points summarize the best ways to be successful in GC: capillary GC is clean GC; practice, practice, practice; and be a student of GC. Read more


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Storable SPE desalting columns.

Enhanced beds of PROTO™ 300 & TARGA® RPC chemistries eliminate particles which can plug capillary columns. "Equilibrate & Store" or "Run & Save" for reduced sample losses of very small samples. Try our storable BioPureSPN™ RPC & HILIC spin columns in our new, lower cost configurations today. LEARN MORE at The Nest Group, Inc. - "Not Just Columns … Answers!"


Featured News

Analytical Chemists to Receive ACS Awards

The American Chemical Society (ACS) 2018 National Awards will be presented at a ceremony on March 20 in conjunction with the 255th ACS National Meeting in New Orleans. Read more

Application Note

Automated Integrated Workflow for ADC DAR Characterization

Easy-to-use and fully integrated method for the determination of drug to antibody ratios (DARs) of antibody-drug conjugates (ADCs).
• Easy-to-use method for the determination of drug to antibody ratios of ADCs
• Open access automation solution that is specifically designed for biomolecule sample preparation
• BioConfirm software provides automatic calculation of the average DAR for all forms of the ADC
Read more

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Mini "Whisper" Nitrogen Generator

The Mini "Whisper" Nitrogen Generator Produces +99% Pure Nitrogen from Compressed Air with Output to 12 l/min. Applications Include TGA/DSC, LCMS, ELSD and Charged Aerosol Detectors. Eliminate Nitrogen Cylinders Easily. Learn more

Runge Mikron Detectors

This unique line consists of a photometer, a fluorimeter and a conductivity meter. Thanks to its compact size, it can be used directly at the measurement site. Learn more

5-Minute Automated Solvent Extraction

The EDGE extraction system performs solvent extraction in less than 5 minutes, including system setup and sample filtration. The EDGE combines pressurized fluid extraction with dispersive solid phase extraction to achieve remarkable recovery and repeatability. Learn more

UV Absorbance Detector

Low-cost Fixed Wavelength Filter Detector is excellent for monitoring HPLC and Low Pressure or Flash Columns. Preparative or Analytical Flowcells. Wavelengths available (214, 230, 254 280nm and more). OEM configurations available. Learn more

EXP® Products for UHPLC

EXP® Family includes hand-tight fittings, filters, traps and guards rated to 20,000+psi. This advanced system is the only design to provide reusable hand-tight connections and hand-tight cartridge replacement for UHPLC pressures.
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New PerkinElmer Clarus GC Systems

Clarus® 590 and 690 GC instruments include powerful new features to deliver superior sensitivity, capacity, and throughput – plus added versatility with the TurboMatrix™ MultipPrep Autosampler for liquid injection, headspace and solid-phase micro-extraction (SPME). Learn more

µPAC™ - Unprecedented separation power

PharmaFluidics' game-changing chip-based chromatography column for nano-LC, lets you detect more molecules in tiny, complex biological samples. High resolution separations are obtained, perfect for lipidomic, metabolomic and peptide profiling. Learn more

New Webcasts

A New Technology, Energized Dispersive Extraction, for Rapid, Simple, and Efficient Sample Preparation

Tuesday, February 13, 2018 | 11 am EST | 10 am CST | 8 am PST
Register>>

Short Chain Chlorinated Paraffins – a High Resolution Orbitrap GC-MS Solution

Wednesday, February 14, 2018 | 11 am EST | 8 am PST | 1600 GMT | 1700 CET
Register>>

Advancing Food Testing Using New and Unique GC Column Selectivities

Tuesday, February 20, 2018 | 11 am EST | 8 am PST | 1600 GMT | 1700 CET
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Address the Paradigm Shift in Regulatory Inspections

Wednesday, 28 February, 2018 | 11 am EST | 1600 GMT | 2130 IST
Register>>

Real-Time Monitoring of Volatile Compounds in the Workplace Using Direct MS

Wednesday, 7 March, 2018 | 1300 GMT | 1400 CET
Register>>

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