LCGC North America Application Note Alert Having trouble viewing this email? Click here U/HPLC Workflow Solution for Biosimilar Characterization The molecular similarity between Humira® and Yervoy® biosimilars and the corresponding innovator reference products is examined using SEC, RPC and HIC. Biosimilar Analysis Using SEC In this application note, a TSKgel® UP-SW3000 SEC column is used to elucidate the molecular similarity between Humira and Yervoy biosimilars and the reference products. Quality Control of mAbs Using SEC This application note compares analyte recovery and resolution between a traditional QC HPLC-SEC method and an updated QC UHPLC-SEC method. ADC Characterization Using SEC and HIC An ADC mimic is analyzed by size exclusion chromatography/mass spectrometry (SEC/MS) and by HIC for DAR profile verification. SEC Analysis of a Bispecific Antibody In this application note, a bispecific T cell engager (BiTE®) is analyzed by SEC/MS using a TSKgel UP-SW3000, 2 μm column.