LCGC North America Application Note Alert Having trouble viewing this email? Click here   HPLC QbD and Impurity Control Strategy Development A new software application helps teams address the challenge of process and impurity data management while following a QbD approach and enhancing collaboration. Revealing Impurities Concealed by API Peak This application note shows how 2D-LC can separate and quantify two compounds with similar structures and retention behavior but with widely different concentrations. Agilent Single Quadrupole Walkup for Multi-User Labs This App Note discusses the 6120B Single Quadrupole Walkup system, and its practical use for applications including the analysis of chemical libraries. Aflatoxin Assay Using a Low-Cost Fluorescence Detector An isocratic HPLC method for the analysis of aflatoxins. Uses the DFL-10 (filter fluorescence detector) with a photochemical reactor to improve sensitivity. First Silanol-Free High pH Silica-Based C18 Column Here, we introduce Dacapo DX-C18 with Dual-Matrix technology, a polymer/silica particle with no exposed silanols, and excellent stability from low to high pH ranges. Separation of THC Isomers on Cogent C18 THC has several isomeric forms that can be separated from the main peak using the Cogent Bidentate C18 column with a high amount of organic solvent, easily and precisely. LC Trapping: A General Guide Trap columns are a convenient means of handling a variety of on-line or off-line sample clean-up and enrichment processes at HPLC and UHPLC pressures. A Rugged 4-Min Method for High-Throughput Labs The dilute-and-shoot EtG and EtS LC–MS/MS analysis developed here using the novel Raptor EtG/EtS column easily resolves EtG and EtS from matrix interferences. Multimodal Column for Polar Anionic Substances Shodex introduces the HILICpak VN-50 series with more rugged packing material than zwitterion type columns, ideal for neurotransmitter analysis.   Hyphenated Screening Analysis of Highly Polar Doping Agents in Urine Using 2D LC–MS/MS This application note highlights 2D LC–MS/MS for the simultaneous analysis of highly polar doping agents and adrenergic agents.   Sample Prep LC/MS/MS Analysis of THC in Whole Blood This note describes how Agilent Captiva EMR—Lipid removed over 97% of unwanted phospholipids from the whole blood matrix with over 92% recoveries of target analytes. Pain Management Panel Testing Methods A simple, high throughput sample preparation method has been developed and validated for quantitation of drugs of abuse and metabolites using Panthera SPE plate. Removal of Purple Pigmentation from Cannabis using a QuEChERS Extraction This application note outlines a QuEChERS extraction procedure for the analysis of 5 mycotoxins and 47 pesticides in cannabis.   GC Analysis of N-Nitrosamines in Beer and Malt Nitrosamines are a group of carcinogenic and mutagenic compounds. These compounds can be formed in malt during the malting process and then potentially be passed onto the final beer product. This application looks at how the 800 series TEA can be used to test for these compounds to ensure product safety and compliance. Using High-Performance GC-TOFMS to Effectively Monitor Patient Opioids and Other Drug Classes The speed, resolution, and robustness of the Pegasus® BT GC-TOFMS was used to increase complex sample throughput and provide confidence in drug analysis results.   General Turbo Pump Basics: Installation, Operation, Start/Stop & Venting This application note describes the basic care and use of turbomolecular high vacuum pumps, including installation, operation, starting, stopping and venting.