In our December issue:
COLUMNS
Column Watch
Drawing A Better Map: Recent Advances in Protein Digestion and Peptide Mapping
Cory E. Muraco
New strategies for "bottom-up" analysis of therapeutic proteins, using faster enzymes, new buffer systems, and optimal column chemistries, enable analysts to perform these studies much faster and with fewer artifacts.
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Exclusive Interview from ASMS 2018
Transform Small Molecule Characterization and Identification in Drug Development
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LC Troubleshooting
Letting the Chromatograph Talk, Part I: Looking for Troubleshooting Clues in Unexpected Places
Dwight R. Stoll
An ultraviolet (UV) detector signal can be an excellent source of clues for troubleshooting problems with your LC–even if you are using a mass spectrometer. We also share another good source of clues.
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The Essentials
How It Works: UV Detection for HPLC
The fundamental principles of UV detection are explained, in a single page.
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PEER-REVIEWED ARTICLES
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Development of a Multi-Product SE-UHPLC Method for the Determination of Size-Variants in Bispecific Antibody Formats
Tobias Graf, Raphael Ruppert, Alexander Knaupp, Georg Hafenmair, Sebastien Violini, Steffen Kiessig, Markus Haindl, Harald Wegele, and Michael Leiss
The versatile size-exclusion ultrahigh-performance liquid chromatography (SE-UHPLC) platform method described here provides superior separation for bispecific monoclonal antibody formats compared to a previous method.
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Statistics for Analysts Who Hate Statistics, Part VII: Sum of Ranking Differences (SRD)
Caroline West
The sum of ranking differences (SRD) is a useful statistical tool for comparing methods, models, columns, or samples. It is also simple and straightforward.
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Features
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Lloyd R. Snyder (1931-2018)–A Personal Tribute
John W. Dolan
Lloyd Snyder was one the "founding fathers" of high performance liquid chromatography (HPLC). He was one of the most widely cited chromatographers with many impo0rtant contributions to the field of separation science.
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Deep in the Heart of Texas, Chromatography Advances
Kevin A. Schug
The 2019 ISCC and GCxGC Symposia, May 12–17, 2019, in Fort Worth, Texas, promise to provide an exciting and relevant venue for discussions of the latest developments in chromatography.
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Ease Routine Analysis of Phthalates in Vegetable Oil with Enhanced Sensitivity and Robustness from Single Quadrupole GC-MS Advanced EI source
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Leveraging Exception Reporting to Optimize Chromatography Data Review
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