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In our December issue:

COLUMNS

LC Troubleshooting
Effects of Flow Rate on UV Detection in Liquid Chromatography
Dwight R. Stoll
A deeper theoretical understanding of the relationship between peak area and flow rate will help analysts diagnose problems when using UV absorbance detection.

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Good Water Practices for Reliable LC–MS and ICP-MS Analyses
Tuesday, December 3, 2019 at 11am EST | 8am PST | 4pm GMT | 5pm CET
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Perspectives in Modern HPLC
Chromatography Data Systems: Perspectives, Principles, and Trends
Robert P. Mazzarese, Steven M. Bird, and Michael W. Dong
This technical overview of chromatography data systems (CDS) looks at how CDS are designed, how they can be used most effectively, and what developments we can expect in the future.

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Thermal Desorption-Direct MS: A Breakthrough in Analysis Speed and Throughput
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Focus on Food Analysis
Studying Migration of Packaging Components into Food
Laura Bush
Perfecto Paseiro Losada and his group at the University of Santiago de Compostela, in Spain, describe their investigations into the kinetics of how packaging compounds migrate into foods and their studies to estimate dietary exposure.

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Platform Purification Approaches for the Production of Complex Biologics
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The Essentials
The Basics of HPLC Peptide Analysis
Fundamentals aspects of using HPLC techniques for protein analysis are described as they relate to the analysis of post-translational modifications (PTMs) and glycoprofiles.
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Access Monoclonal Antibody Quality Attributes with HRMS Analytical Power
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Peer-Reviewed Articles
Determination of PAHs in Combustion-Related Samples via Multidimensional Chromatographic Methods
Hugh V. Hayes, Walter B. Wilson, Lane C. Sander, Stephen A. Wise, and Andres D. Campiglia
Gas chromatography–mass spectrometry (GC–MS), reversed-phase LC with stop-flow fluorescence (FL), and constant energy synchronous fluorescence spectroscopy (CESFS) are explored to determine PAH isomers in three combustion-related standard reference materials.
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Capillary Flow LC–MS Using Micro Pillar Array Columns: Combining Nano Flow Sensitivity with Analytical Flow Robustness and Throughput
Friday, December 13, 2019 at 10am EST | 9am CST | 3pm GMT | 4pm CET
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Clinical Metabolomics: Expanding the Metabolome Coverage Using Advanced Analytical Techniques
Rob Haselberg, Bob W.J. Pirok, Andrea F.G. Gargano, and Isabelle Kohler
Clinical metabolomics requires analytical methods that provide both high resolution and high throughput. In this review, we assess the promise of a variety of techniques—including HILIC, SFC, multidimensional LC, ion-mobility mass spectrometry, and data-independent acquisition mass spectrometry methods—to meet those needs.

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Editors’ Series: Helium to Hydrogen: A Change Would Do You Good
Wednesday, December 18, 2019 at 11am EST| 8am PST| 4pm GMT| 5pm CET
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NEW WEBCAST
Editors’ Series: Helium to Hydrogen: A Change Would Do You Good
Wednesday, Dec. 18, 2019 at 11 am EST | 8 am PST | 4 pm GMT | 5 pm CET
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ON DEMAND WEBCASTS
Does Your Electronic Data System Meet 21 CFR Part 11 and CGMP Requirements?
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Multi-Detector SEC Characterization of Polymer Architectures
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Identifying and Quantifying Aspartate and Iso-Aspartate Isomers and Other Difficult PTMs in Proteins
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If you would like to submit an article to LCGC, contact Laura Bush, Editorial Director - LBush@mmhgroup.com

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