In our November issue:
COLUMNS
LC Troubleshooting
Column Re-equilibration Following Gradient Elution: How Long is Long Enough?
Part I: Reversed-phase and HILIC Separations of Small Molecules
Dwight R. Stoll and Claudia Seidl
Many users have questions about how long LC columns should be re-equilibrated following solvent gradient elution separations. Here we show satisfactory results with short re-equilibration periods, for both reversed-phase and HILIC separations.
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Sample Prep Perspectives
The (Mis)education of an Analyst
Douglas E. Raynie
Proper sample preparation is vital. We look at formal and informal training opportunities to educate chemists in the fundamentals of sample preparation skills.
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GC Connections
Online LC–GC: The Ultimate “GC Connection”
Atsu Apedo and Nicholas H. Snow
Multidimensional chromatography combining HPLC and GC, or LC–GC, sounds simple, but several factors complicate this combination, including solvent compatibility, separation time, and sample concentration.
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Non-targeted Screening for Environmental Water Quality Monitoring
Thursday, November 14, 2019 at 11am EST | 8am PST | 4pm GMT | 5pm CET
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Focus on Biopharmaceutical Analysis
Utility of Hydrogen-Deuterium Exchange Together with Mass Spectrometry for Determining Higher Order Structures of Proteins: Comparisons Between Biosimilar and Innovator Biopharmaceuticals
J. Auclair, A. Rathore, and I.S. Krull
Hydrogen–deuterium exchange–mass spectrometry enables determination of higher order structures of biopharmaceuticals and direct comparisons between a biosimilar and its proprietary analog.
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RPLC Method Development Strategies Using Stationary Phase and Mobile Phase Screening, and Some Helpful Tools and Tips
Wednesday, November 13, 2019 at 1pm EST| 12pm CST| 10am PST
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Focus on Food Analysis
Keeping Up with Evolving Challenges in Pesticide Analysis
Laura Bush
Jim Garvey of the Pesticide Control Laboratory in Ireland discusses the development of pesticide analysis methods with high-resolution accurate mass MS.
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Identifying and Quantifying Aspartate and Iso-Aspartate Isomers and Other Difficult PTMs in Proteins
Thursday, November 7, 2019 at 11am EST | 8am PST | 4pm GMT | 5pm CET
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The Essentials
Three Top HPLC Method Development Tips
These three tips provide a clear starting point developing any HPLC method, to achieve optimum resolution in the minimum amount of time.
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How to Approach Preparative LC for Compound Purification in the Research and Development Laboratory
Thursday, November 7, 2019 at 11am EST | 8am PST | 4pm GMT | 5pm CET
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Peer-Reviewed Article
Chromatography Fundamentals, Part VIII: The Meaning and Significance of Chromatographic Resolution
Howard G. Barth
The effectiveness of a separation can be quantified by measuring the resolution.
This article explains the factors influencing resolution and the equation for
predicting the required number of theoretical plates to obtain a given esolution.
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Applications of Field Flow Fractionation
Tuesday, October 29, 2019 at 11am EDT | 8am PDT| 3pm GMT| 4pm CET
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| NEW WEBCASTS |
Good Water Practices for Reliable LC–MS and ICP-MS Analyses
Tuesday, Dec. 3, 2019 at 11 am EST | 8 am PST | 4 pm GMT | 5 pm CET
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Platform Purification Approaches for the Production of Complex Biologics
Wednesday, Dec. 4, 2019 at 8:30 am IST | 11 am CST | 12 pm KST | 2 pm AEDT
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Access Monoclonal Antibody Quality Attributes with HRMS Analytical Power
Thursday, Dec. 5, 2019 at 11 am EST | 8 am PST | 4 pm GMT | 5 pm CET
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Thorough and Reproducible Analytical Characterization of Innovator and Biosimilar Pair
Europe Broadcast: Wednesday, Dec. 11, 2019 at 2 pm GMT | 3 pm CET
North America Broadcast: Wednesday Dec. 11, 2019 at 2 pm EST| 1 pm CST | 11 am PST
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| ON DEMAND WEBCASTS |
Does Your Electronic Data System Meet 21 CFR Part 11 and CGMP Requirements?
On Demand
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Multi-Detector SEC Characterization of Polymer Architectures
On Demand
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Identifying and Quantifying Aspartate and Iso-Aspartate Isomers and Other Difficult PTMs in Proteins
On Demand
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How to Approach Preparative LC for Compound Purification in the Research and Development Laboratory
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Applications of Field-Flow Fractionation
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HPLC Detectors – What, Where, When, and How
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If you would like to submit an article to LCGC, contact Laura Bush, Editorial Director - LBush@mmhgroup.com
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