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In our July issue:

COLUMNS

Column Watch
Hybrid Particle Columns: The First Twenty Years
Thomas H. Walter
We examine the evolution of hybrid particle columns, highlighting examples of separations enabled by this technology.

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Accurate, Sensitive GC-MS Series
Utilizing the most advanced gas chromatograph available, and incorporating a variety of technological advances, Shimadzu's NX series of single-quad and triple-quad GCMS instruments offers the highest performance levels available. And, with a variety of Smart features, easy maintenance, and intuitive software, these systems provide more efficient workflows, greater uptime, and reduced costs for higher productivity and better ROI. Learn more
LC Troubleshooting
Mobile Phase Buffers in LC: Effect of Buffer Preparation Method on Retention Repeatability
Dwight R. Stoll and Devin M. MakeyGregory Webster, and Dwight R. Stoll
An in-line mixer between the sample injector and column may resolve problems with peak shape caused during sample dilution.

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Exclusive Videos: Novel Applications for CESI–MS Analysis
At the most recent Global CESI-MS Symposium, researchers explored the use of CESI–MS analysis to characterize monoclonal antibodies, to quantify highly polar pesticides, to identify post-translational protein modifications, to detect pesticide metabolites, and much more. Watch now
GC Connections
Temperature Programmed GC: Why Are All Those Peaks So Sharp?
Nicholas H. Snow
Temperature programming is used in most capillary GC separations, but many analysts lack a good understanding of the principles behind this approach.

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Multi-Detector SEC Characterization of Polymer Architectures
Tuesday, July 30, 2019 at 11am EDT | 8am PDT | 4pm BST | 5pm CEST
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Focus on Environmental Analysis
Environmental Method Development: Key Challenges and Unmet Needs
Michael MacRae
The environmental analysis community sorely needs a system by which new and up-to-date methods are more easily developed, shared, and adopted.

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Does Your Electronic Data System Meet 21 CFR Part 11 and CGMP Requirements?
Thursday, June 13, 2019 | North America: 1pm EDT | Europe: 6pm BST
Thursday, July 25, 2019 | North America: 9am EDT | Europe: 3pm CEST India: 6:30pm IST
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The Essentials
Electron Capture Detectors
The fundamentals of electron capture detectors, explained.
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High-Throughput, Automated Volatiles Analysis from Air, Headspace and Thermal Desorption Tubes
Tuesday, July 23, 2019 at 11am EDT | 8am PDT | 4pm BST | 5pm CEST
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Peer-Reviewed Articles
The Determination of Trace Per- and Polyfluoroalkyl Substances and Their Precursors Migrated into Food Simulants from Food Contact Materials by LC–MS/MS and GC–MS/MS
Dan Li, Zi-hao Zhang, Huai-ning Zhong, Lei Zhu, Jing-jing Pan, Jian-guo Zheng, Qin-bao Lin, and Hui Liu
This integrated analytical approach combines HPLC–MS/MS and GC–MS/MS to detect 36 PFAS migrating into food simulants from packaging.

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Chromatography Fundamentals, Part VII: Influence of Peak Broadening on Detection Sensitivity, Solute Dilution, and Efficiency of Coupled Columns
Howard G. Barth
With these equations, you can predict how solute dilution will affect sensitivity.

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Feature Article
Under Pressure to Perform: Impact of UHPLC Technology on Pharmaceutical Research and Development
Christopher J. Welch
How has UHPLC has affected pharmaceutical research? The answer depends on your point of view.

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LIVE WEBCASTS
Does Your Electronic Data System Meet 21 CFR Part 11 and CGMP Requirements?
Thursday, July 25, 2019 | North America: 9 am EDT | Europe: 3 pm CEST | India: 6:30 pm IST
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Multi-Detector SEC Characterization of Polymer Architectures
Tuesday, July 30, 2019 at 11 am EDT | 8 am PDT | 4 pm BST | 5 pm CEST
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Developing a Robust CQA Monitoring Method via Multi-Attribute Monitoring Principles for Therapeutic Monoclonal Antibody Development, Manufacturing, and Lifecycle Management
Tuesday, Sept. 10, 2019 at 11am EDT | 8am PDT | 4pm BST | 5pm CEST
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ON DEMAND WEBCASTS
Analysis of Underivatized Biogenic Amines by LC–MS/MS Using an Alternative Ion-pairing Chromatography Technique
On Demand
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Editors' Series: Water, Water Everywhere: Good Practice with Water in the Analytical Lab
On Demand
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Application of New Mass Spectrometric Methods and Workflows to Determine Authenticity of Food
On Demand
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HPLC Method Development: Practical Approaches for Identifying Equivalent and Orthogonal Columns
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If you would like to submit an article to LCGC, contact Laura Bush, Editorial Director - LBush@mmhgroup.com

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