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In our April issue:

COLUMNS

LC Troubleshooting
Selectivity in Reversed-Phase Liquid Chromatography: 20 Years of the Hydrophobic Subtraction Model
Dwight R. Stoll
The hydrophobic subtraction model has been very successful. Nevertheless, the accompanying public database, which has parameters for 750 commercially available columns, is an underutilized column characterization tool. Here is some guidance on how to use both the model and the free database.

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Column Watch
New Chromatography Columns and Accessories for 2020
David S. Bell
We explore what’s new in the liquid chromatography columns and accessories commercially released over the past year.

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Pesticide Analysis Using a GC-Triple Quadrupole Mass Spectrometer
Tuesday, April 14, 2020 at 11am EDT | 8am PDT | 4pm BST | 5pm CEST
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Perspectives in Modern HPLC
New HPLC Systems and Related Products Introduced in 2019–2020: A Brief Review
Michael W. Dong
Our annual review of new high performance liquid chromatography and mass spectrometry instruments, chromatography data systems (CDS), and related

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Setting Up a GC Instrument for Analysis
Thursday, April 30, 2020 at 11am EDT | 8am PDT | 4pm BST | 5pm CEST
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Focus on Environmental Analysis
Advancing Nontargeted Analysis of Water
Laura Bush
LC–MS techniques, particularly those using high-resolution MS and nontargeted analysis, are advancing many areas of water research. Here, Imma Ferrer of the University of Colorado shares some of her recent work in this field.

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Implementing Attribute Monitoring Analyses for Biopharmaceutical Development and QC
Wednesday, April 29, 2020, 9am EDT| 2pm BST| 3pm CEST
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Fundamentals
Preparing for GC Analysis—A Definitive Checklist
Tony Taylor
In-depth knowledge of GC setup is a significant advantage for the user. Here, a checklist is provided for preparation of a GC or GC–MS system prior to analysis work— referencing the actions, checks, tools, and consumable items that might be required.

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GC Method Advancements for the Analysis of Environmental Matrices in the Industrial Landscape
Wednesday, April 22, 2020 at 11am EDT| 8am PDT| 4pm BST| 5pm CEST
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FEATURED ARTICLE

Understanding the Lifecycle Approach for Analytical Procedures
R.D. McDowall
A key component for data integrity is having accurate and precise analytical procedures that are validated for intended use. Changes in the way that procedures are specified, developed, validated, and operated are coming. Here is what you need to know.

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An In-Depth Look at Intact Biotherapeutic Characterization and Quantitation in Biological Matrices
Europe Broadcast: Thursday, April 23, 2020 at 9am EDT | 2pm BST | 3pm CEST
US Broadcast: Thursday, April 23, 2020 at 2pm EDT | 1pm CDT | 11am PDT
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PEER-REVIEWED ARTICLE

Overview of Methods and Considerations for Handling Complex Samples
Jamie L. York and Kevin A. Schug
When working with complex samples, we need effective approaches to deal with matrix interferences. Here, we outline methods of sample preparation, on-line sample treatment, and instrument tools that can help. We also provide examples of applications and guidance for how to evaluate the best option for your complex sample.

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NEW WEBCASTS
Advances in Gas Chromatography for Separation of Challenging Analytes in the Pharmaceutical, Environmental, Cannabis, and Food Industries
Friday, Apr. 24, 2020 at 11 am EDT | 8 am PDT | 4 pm BST | 5 pm CEST
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How to Build a Cannabis Testing Laboratory
Tuesday, Apr. 28, 2020 at 2 pm EDT | 1 pm CDT | 11 am PDT
Tuesday, May 5, 2020 at 2 pm EDT | 1 pm CDT | 11 am PDT
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Practical Method Development Strategies for the Analysis of Monoclonal Antibodies by Reversed-Phase HPLC
Thursday, May 21, 2020 at 11 am EDT | 8 am PDT | 4 pm BST | 5 pm CEST
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ON DEMAND WEBCAST
Editors’ Series: Coping with COVID-19: Remaining Productive and Safe in the Analytical Laboratory
On Demand
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Editors’ Series: Limiting Laboratory Exposure: A Chemist’s Guide to the COVID-19 Outbreak
On Demand
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Improve Productivity through Automated Ion Chromatography (IC)
On Demand
Learn More »»

If you would like to submit an article to LCGC, contact Laura Bush, Editorial Director - LBush@mmhgroup.com

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