In our February issue:
COLUMNS
LC Troubleshooting
Reversed-Phase Liquid Chromatography and Water, Part I: How Much is Too Much?
Dwight R. Stoll
In reversed-phase separations, retention generally increases as the fraction of water in the eluent increases. When we encounter situations where retention is too low for an analyte of interest, we tend to use eluents with higher and higher levels of water. But how much water is too much?
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GC Connections
GCxGC: From Research to Routine
Nicholas H. Snow
Two-dimensional gas chromatography (GCxGC) is becoming the technique of choice for analysis of highly complex samples such as petroleum, pharmaceuticals, biological materials, food, flavors, and fragrances. Here, we explain how GCxGC works and provide examples that illustrate its advantages.
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Achieving PEEK-like Performance on Stainless Steel HPLC Components with Bio-Inert CVD Coatings
Thursday, February 28, 2019 at 11am EST| 8am PST| 4pm GMT| 5pm CET
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The Essentials
Optimizing Sensitivity in GC–FID Analysis
It is often possible to achieve better sensitivity and lower limits of detection and quantitation using standard gas chromatography instrumentation. Paying attention to fundamental variables—like sample solvent, initial oven temperature hold, carrier gas operating mode, and thermal gradients—can lead to much improved method performance.
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Native Mode Mass Spectrometry Analysis
Wednesday, February 27, 2019 at 11am EST| 8am PST| 4pm GMT| 5pm CET
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Featured Articles
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The 2019 LCGC Awards
Jerome Workman Jr.
The contributions of Milos V. Novotny and Ken Broeckhoven, the winners of the 2019 LCGC Lifetime Achievement and Emerging Leader in Chromatography Awards, are presented.
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The Importance of Computer System Validation for Regulated Systems
Three Live Dates: Europe: Tuesday, February 26, 2019 at 2pm GMT| 3pm CET
North America: Tuesday February 26, 2019 at 2pm EST|1pm CST|11am PST
Asia Pacific: Wednesday, February 27, 2019 at 8:30am IST| 11am CST| 12pm JST
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Data Integrity Focus, Part II: Using Data Process Mapping to Identify Integrity Gaps
R.D. McDowall
Data integrity is paramount when working in a regulated environment. Data process mapping is an excellent way to identify and mitigate data gaps and record vulnerabilities in a chromatographic process. This approach is simple and practical.
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Extraction of Pesticides from Difficult Food Matrices
Thursday, February 21, 2019 at 11am EST | 8am PST | 4pm GMT | 5pm CET
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THE APPLICATION NOTEBOOK
Turn to page 131 for the LCGC February Application Notebook
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A Streamlined Approach for Reversed-Phase Method Development Using a Combined Column Screening and Software Modelling Approach
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A Multi-mode LC Approach to Biosimilar Characterization
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A Rapid, Simple, and Efficient Extraction Method for Additives in Plastics
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Screen Hundreds of N-Glycans per Day: More Samples – Better Decisions – Faster
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Optimizing SEC for Analysis of Antibodies and Antibody–Drug Conjugates
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Probing Submicron Protein Aggregation Using Asymmetrical Flow Field-Flow Fractionation (AF4) and Light Scattering
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Moving to the Cloud: Key Considerations
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Ease Routine Analysis of Phthalates in Vegetable Oil with Enhanced Sensitivity and Robustness from Single Quadrupole GC–MS Advanced EI source
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| Turn to page 131 for the LCGC February Application Notebook |
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| LIVE WEBCASTS |
The Importance of Computer System Validation for Regulated Systems
Live Europe: Tuesday, Feb. 26, 2019 at 2 pm GMT | 3 pm CET
North America: Tuesday Feb. 26, 2019 at 2 pm EST | 1 pm CST | 11 am PST
Asia Pacific: Wednesday, Feb. 27, 2019 at 8:30 am IST | 11 am CST | 12 pm JST
 Sign Up Here »» |
Native Mode Mass Spectrometry Analysis
Wednesday, Feb. 27, 2019 at 11 am EST| 8 am PST| 4 pm GMT| 5 pm CET
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Achieving PEEK-like Performance on Stainless Steel HPLC Components with Bio-Inert CVD Coatings
Live Europe: Thursday, Feb. 28, 2019 at 11am EST | 8 am PST | 4 pm GMT | 5 pm CET
Sign Up Here »» |
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