In our February issue:
COLUMNS
LC Troubleshooting
Effects of Buffer Capacity in Reversed-Phase Liquid Chromatography, Part I: Relationship Between the Sample- and Mobile-Phase Buffers
Dwight R. Stoll and Thomas J. Lauer
We return to the important topic of buffers, this time focusing on what happens when there is a mismatch between the mobile-phase buffer pH and the pH that the sample is buffered at.
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Column Watch
State-of-the-Art in Capillary Liquid Chromatography: Now, Next, and How?
James P. Grinias, Justin M. Godinho, Fabrice Gritti, Purnendu K. Dasgupta, Kevin A. Schug, and David S. Bell
At the 43rd International Symposium on Capillary Chromatography (ISCC 2019) in Fort Worth, Texas, a panel addressed the current challenges and potential future directions in capillary liquid chromatography. How can their vision be achieved?
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Using Selectivity to Optimize Resolution for Improved LC and LC–MS Method Development with Superficially Porous Particles
Thursday, February 13, 2020 at 1pm EST| 12pm CST| 10am PST
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Viewpoints
Commercial Sample Preparation Materials for Isolation of Intact Proteins from Biological Samples are Absent in the Marketplace
Kevin A. Schug
A top-down approach to quantifying intact proteins from biological fluids using liquid chromatography–triple quadrupole–mass spectrometry (LC–MS/MS) offers the potential for more absolute quantitation than bottom-up approaches. To make this broadly viable, however, commercial sample preparation tools are needed.
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Achieving Metal Free HPLC Analysis with a Bio-inert Chemical Vapor Deposition Coating
Tuesday, February 25, 2020 at 11am EST | 8am PST | 4pm GMT | 5pm CET
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Featured Articles
Nightmare on Lab Street—Are You Haunted by Hybrid Systems?
R.D. McDowall
Hybrid chromatography data systems are the worst possible solution for any
laboratory, whether regulated or unregulated, and yet they are pervasive. Here’s why.
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Theory and Practice of Developing LC Methods with Solid-Core Particle Columns
Wednesday, February 26, 2020 at 1pm EST | 12pm CST | 10am PST
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The 2020 Lifetime Achievement and Emerging Leader in Chromatography Awards
Jerome Workman, Jr.
Daniel W. Armstrong and Szabolcs Fekete are the winners of the 13th annual LCGC Lifetime Achievement and Emerging Leader in Chromatography Awards, respectively. Here, we review their achievements.
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Mobile-Phase Selection for Reversed-Phase Liquid Chromatography Methods: What You Need to Know
Friday, February 28, 2020 at 11am EST | 8am PST | 4pm GMT | 5pm CET
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Peer-Reviewed Article
Molecular Weight Analysis of Glatiramer Acetate and Related Compounds by Size-Exclusion Chromatography with Multi-Angle Light Scattering Detection (SEC-MALS)
Joseph L. Glajch, Ying Li, Wing-Yee Fu, Claire Coleman, Mani Iyer, Harper Kaminski, Jason Todd, and Timothy Rumfeldt
A method was developed for the molecular weight characterization of heterogeneous polymer mixtures, such as heparins and glatiramer acetate, noting that single molecular structures are not adequate for creating a molecular weight calibration curve. That limitation is overcome in this work, which demonstrates method validation and application to process samples.
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