In our January issue:
COLUMNS
LC Troubleshooting
Effects of Buffer Capacity in Reversed-Phase Liquid Chromatography, Part I: Relationship Between the Sample- and Mobile-Phase Buffers
Dwight R. Stoll and Thomas J. Lauer
We return to the important topic of buffers, this time focusing on what happens when there is a mismatch between the mobile-phase buffer pH and the pH that the sample is buffered at.
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Sample Prep Perspectives
Sample Preparation Goes Subzero: Ice Concentration Linked with Extractive Stirrer (ICECLES)
Brian A. Logue, Chris Skaggs, and Abdullah H. Alluhayb
A new technique, ICE concentration linked with extractive stirrer (ICECLES), provides highly efficient isolation of trace compounds from aqueous samples. ICECLES combines freeze concentration with stir-bar sorptive extraction into a seamless analytical extraction methodology.
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Tips & Tricks and Troubleshooting for Improved MS Sensitivity
Thursday, January 30, 2020 at 11am EST | 8am PST | 4pm GMT | 5pm CET
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GC Connections
Thirty-two Years Connecting with Gas Chromatography
John V. Hinshaw
After 32 years as a columnist, John Hinshaw writes his final “GC Connections” article, examining how GC has changed over the years and considering where it might go in the future.
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Advanced analytical workflow solutions for monitoring critical quality attributes of monoclonal antibodies
Europe: Wednesday, February 5, 2020 at 2pm GMT | 3pm CET
US: Wednesday, February 5, 2020 at 2pm EST | 1pm CST | 10am PST
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Focus on Biopharmaceutical Analysis
A Review of Recent Developments in Analytical Characterization of Glycosylation in Therapeutic Proteins
Anurag S. Rathore, Ira Krull, and Niharika Budholiya
Advanced separation and mass spectrometry methods enable comprehensive profiling of the inherent glycan heterogeneities of protein therapeutics. In particular, reversed-phase HPLC–based multiattribute methods (MAMs) provide a wealth of information, and other techniques, such as HILIC and CE-MS, also continue to evolve.
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Using Selectivity to Optimize Resolution for Improved LC and LC–MS Method Development with Superficially Porous Particles
Thursday, February 13, 2020 at 1pm EST| 12pm CST| 10am PST
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Focus on Data Handling
The Current Landscape of Data Integrity
A look at how data integrity requirements and the focus of data integrity have changed over the past five years.
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Peer-Reviewed Article
Technical Challenges Encountered During Chromatographic Method Transfers to Pharmaceutical Manufacturing Sites
Peter Tattersall, Jia Zang, and Brent Kleintop
Drug substance development requires a complex range of analytical methods, presenting a challenge to analytical chemists to reliably transfer and execute these fit-for-purpose methods to external manufacturing sites. Here, we provide guidelines to follow, and share examples of real-world problems and the strategies used to remedy them
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Tips & Tricks and Troubleshooting for Improved MS Sensitivity
Thursday, Jan. 30, 2020 at 11 am EST | 8 am PST | 4 pm GMT | 5 pm CET
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Advanced Analytical Workflow Solutions for Monitoring Critical Quality Attributes of Monoclonal Antibodies
Europe: Wednesday, Feb. 5, 2020 at 2 pm GMT | 3 pm CET
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The CHROMacademy Essential Guide Webcast: Native and Denaturing Mode Size Exclusion Analysis of Biotherapeutics
North America: Wednesday, Feb. 12, 2020 at 11am EST | 10am CST | 8am PST
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Access Monoclonal Antibody Quality Attributes with HRMS Analytical Power
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Platform Purification Approaches for the Production of Complex Biologics
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Good Water Practices for Reliable LC–MS and ICP-MS Analyses
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In a Pickle with Pesticides Sample Prep? Achieve Higher Recoveries with Rapid, Automated Extraction of Any Food Matrix
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Editors’ Series: Strategies for Improved Pharmaceutical Sample Preparation
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Thermal Desorption-Direct MS: A Breakthrough in Analysis Speed and Throughput
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