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Presented by LCGC and Spectroscopy

Featured Articles Towards Automated Routine Analysis of the Distribution of Trace Elements in Single Cells Using ICP-MS Analysis of the compositional variation in living cells is essential for understanding biological processes. Single-cell elemental analysis by triple-quadrupole ICP-MS is emerging as a selective, highly sensitive, and potentially high-throughput technique for the study of constitutive elements, and uptake of metallodrugs (or metal-containing nanomaterials) in single cells. read more

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Rapid Quantitation of PFAS in Non-Potable Waters

The presence of per- and polyfluoralkyl substances (PFAS) in water is an important health and environmental concern. Liquid chromatography–mass spectrometry (LC–MS) has been established as the most suitable technology for monitoring these substances. A method is described, using EPA 8327, for PFAS analysis in groundwater, surface water, and wastewater.
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Affinity Selection-Mass Spectrometry: Defining the Bioactive Compounds in Complex Mixtures of Natural Products and Combinatorial Libraries

Drug discovery using high-throughput screening of discreet compounds, and the discovery of natural products with pharmacological mechanisms of action, rely on bioassay-guided fractionation analysis. Recent applications of affinity selection–mass spectrometry (AS-MS) are useful for exploring the discovery of ligands to membrane-bound proteins and RNA targets.
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GC×GC–TOF-MS and Comprehensive Fingerprinting of Volatiles in Food: Capturing the Signature of Quality

Food quality differences are dependent on botanical and geographical origins of primary food ingredients as well as storage and handling. Quality assessment for food materials, including cocoa and olive oil, ids demonstrated by applying two-dimensional gas chromatography (GXxGC) combined with time-of-flight mass spectrometry (TOF-MS) and patter recognition.
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Application Notes Trapped Ion Mobility Combined with LC–HRMS This RAFA 2019 winner of the Best Poster Award, reviews the identification and characterization of secoiridoids isomers found in Greek extra virgin olive oil (EVOO). Download the application note. LCMS Concentration Studies with RSA Glass Using RSA™ glass vials virtually eliminates adsorption issue without surface treatments or vial deactivation like silanizing, which can leach into instruments and columns. Download the application note. Eliminate the Impact of Instrument-Related PFAS Interferences This article explains how the PFAS delay column can improve trace-level PFAS analysis by removing the impact of system-related interferences. Download the application note. PAH Analysis Using Hydrogen as a Carrier Gas Using RSA™ glass vials virtually eliminates adsorption issue without surface treatments or vial deactivation like silanizing, which can leach into instruments and columns. Download the application note. Lab Coping Helium Shortage Note discusses how labs are coping with the worldwide helium shortage. Download the application note.