LCGC North America Application Note Alert Having trouble viewing this email? Click here Improving Selectivity for Intact Mass Spectrometry of Biotherapeutic mAbs Multiple C4 LC columns are compared to determine which provides the necessary separation of the impurity and avoids any spectral overlap in the MS detector. Comparison of UHPLC Particles for Intact Mass Subunit Analysis of Monoclonal Antibodies Comparing core-shell superficially porous to fully porous particles to determine efficiency required for detection and separation of low-level impurities for subunit analysis. Chromatography Optimization for Intact Mass Analysis of Monoclonal Antibodies Analyzing diverse method parameters, such as temperature, gradient program, and flow rates for optimization of intact mass applications when using bioZen WidePore C4. Temperature Effects on Reversed-Phase Separations of Monoclonal Antibodies To overcome peak broadening, this application adjusts the column temperature for the bioZen WidePore C4 to improve peak shape in large molecule reversed-phase applications. Effect of Flow Rate on Reversed-Phase Separations of Monoclonal Antibodies This application analyzes how adjusting the flow rate affects the analysis of intact and reduced NIST mAb when using a bioZen WidePore C4 LC column. Gradient Profile Effects on Reversed-Phase Separations of Monoclonal Antibodies To increase the resolution, this application evaluates and optimizes the gradient program when using a bioZen WidePore C4 LC column. bioZen WidePore C4 Product Brochure bioZen WidePore C4 is built upon core-shell technology with bioinert hardware to offer optimal particle and pore-size morphology for high reproducibility and resolution.   This email was sent by: %%Member_Busname%% %%Member_Addr%%, %%Member_City%%, %%Member_State%%, %%Member_PostalCode%% %%Member_Country%% Privacy Policy Update Profile      Manage Subscriptions      Unsubscribe