|
Top Story
A novel modular bioreactor for dynamic in vitro studies has been set-up, connecting two-dimensional (2D) scaffolds and mimicking a multi-organ model, to study the absorption/metabolization of compounds. The effect of dietary methylglyoxal, a potentially exogenous and endogenous toxic compound, on a dynamic gastro-intestinal system has been evaluated.
Read more
Features
Following a checklist can help to diagnose changes in chromatographic selectivity, which can be among the most difficult to isolate and correct. Read more
Biocompatible LC systems are generally regarded to be chemically more inert than conventional HPLC systems. However, a study into the chromatographic behaviour of some classes of compounds analysed on these iron-free HPLC systems revealed issues typically associated with metal contamination. Read more
| |
|
|
|
Partial coelution of chromatographic peaks is an often-encountered issue in HPLC analysis, despite best efforts in method development and optimization. Even though there are several ways of integration of overlapping signals, accurate quantification of single compounds using conventional PDA detection is almost impossible without baseline separation. While extensive signal processing is well established in spectroscopic analyses such as IR or NMR, it has not yet been commonly adapted to improve chromatographic data evaluation. This article introduces the theory and application of a novel data analysis technique for PDA detection to accurately determine and quantify single compounds, even from overlapping peaks, without the need for MS detection. Read more
|
|
Application Note
 |
This application note presents a novel study of coffee aroma profiling by analyzing volatile organic compounds (VOCs) emitted at a series of progressively higher temperatures.  / Read More / |
|
|
|
Featured Product
 |
Wyatt Technology provides a suite of essential analytical tools for characterizing biologics and complex drugs. Learn more about light scattering tools and techniques used for end-to-end solutions for your applications. 
/ Learn More / |
|
|
|
|
|
