LCGC North America Application Note Alert Having trouble viewing this email? Click here bioZen WidePore C4 Product Brochure bioZen WidePore C4 is built upon core-shell technology with bioinert hardware to offer optimal particle and pore-size morphology for high reproducibility and resolution. Chromatography Optimization for Intact Mass Analysis of Monoclonal Antibodies In this application, temperature, gradient program, and flow rates are explored and optimized for intact mass applications for mAbs when using bioZen WidePore C4. Temperature Effects on Reversed-Phase Separations of Monoclonal Antibodies To overcome peak broadening, this application adjusts the column temperature for the bioZen WidePore C4 to improve peak shape for large molecules. Effect of Flow Rate on Reversed-Phase Separations of Monoclonal Antibodies This application analyzes how to reduce peak widths by adjusting the flow rate for intact and reduced NIST mAb when using a bioZen WidePore C4 LC column. Gradient Profile Effects on Reversed-Phase Separations of Monoclonal Antibodies This application approaches how to achieve better resolution by evaluating and optimizing the gradient program when using a bioZen WidePore C4 LC column.