In this application note we look at the impact that mobile phase concentration has on the sensitivity of SEC-MS when used to analyze intact mAb’s under non-denaturing conditions.
In this application note we look at a method for determining the level of aggregation in a commercially available sample of intact NIST mAb using a bioZen SEC-2 column together with the SCIEX X500B mass spec.
This application note serves to highlight how native MS can be used to get intact mass for non-covalently linked large molecules, including cysteine linked ADCs.
In this application note we show the separation of charge variants of Trastuzumab under native conditions using a pH gradient formed with volatile buffers.
In this application we show the separation of several charge variants of the NIST mAb under native ion exchange and mass spectrometry (high resolution MS) conditions using a pH gradient formed from volatile buffers.
Combining the efficient immunocapture and sample extraction of bioZen MagBeads, trastuzumab is isolated from rat plasma to yields greater selectivity relative to traditional ligand-binding assays.
In this application, Streptavidin coated bioZen MagBeads are utilized for the fast and accurate immunocapture of insulin aspart novolog. By combining immunocapture sample preparation with LC MS/MS, this method demonstrates a functionalized assay that yields greater selectivity and sensitivity.
