LCGC North America Application Note Alert
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LCGC Global
Electrochemical Reduction of S-S Bonds in Biopharmaceuticals
Reagent-free reduction of protein disulfide bond without the use of interfering DTT or TECP for superior peptide sequencing and S-S bond assignment.
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Superior Reduction of Protein Disulfide Bonds in HDX-MS
New electrochemical cell for on-line reduction of disulfide bonds in HDX-MS with significant higher sequence coverage than TECP reduction.
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Electrochemical Mimicking of Cardiovascular Drugs Metabolism
Electrochemical simulation of phase I metabolism of three novel cardiovascular drugs and comparison with in vivo data (human urine) reveals the power of EC-MS.
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Electrochemical Simulation of Triclosan Metabolism
Electrochemical oxidation for fast mimicking of phase I metabolism of Triclosan and its transformation products including their synthesis for toxicological evaluation.
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Electrochemical Synthesis of Metabolites and Degradants
Rapid and cost-effective synthesis of milligram quantities of metabolites or reference materials for structural identification by MS, NMR, or for toxicology studies.
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