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12 December, 2019
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LCGC Blog

The LCGC Blog: Ammonium Acetate Woes

I’ve been dealing recently with issues in the laboratory when using ammonium acetate buffers, including surprising rises in HPLC–MS back pressures when starting the instrument after overnight storage, as well as difficulties with MS sensitivity.
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Features

Environmental Method Development: Key Challenges and Unmet Needs

Whether working in commercial environmental laboratories or academia, many analytical chemists agree that the number and variety of pollutants requiring analysis today is straining the capabilities of current methods and technologies, the introduction of new standard methods is far too slow, and the community sorely needs a system by which new and up-to-date methods are more easily developed, shared, and adopted. These issues were all raised in some recent LCGC roundtable discussions. Read more



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mORE Features

What a GC–MS Tune Report Can Tell You

A tune report is invaluable because it indicates how well the instrument is operating, and is an essential tool when troubleshooting is required. Read more

News

Measuring Chitosan Molecular Weight Using AF4–MALS-RI

A new method for the accurate molecular weight determination of the complex polysaccharides chitosans has been developed using asymmetric AF4 coupled with MALS and differential RI detectors. Read more


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UPCOMING WEBCASTS

Capillary Flow LC–MS Using Micro Pillar Array Columns: Combining Nano Flow Sensitivity with Analytical Flow Robustness and Throughput

Friday, Dec. 13, 2019 at 10am EST | 9am CST | 3pm GMT | 4pm CET
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Editors’ Series: Helium to Hydrogen: A Change Would Do You Good

Wednesday, Dec. 18, 2019 at 11am EST | 8am PST | 4pm GMT | 5pm CET
Register>>

Editors’ Series: What Would an INFRARED-Nosed Reindeer See?

Tuesday, December 17, 2019 at 11am EST| 8am PST| 4pm GMT| 5pm CET
Register>>


ON DEMAND WEBCASTS

Data Management and Integrity Expectations from the World Health Organization and PIC/S


Thorough and Reproducible Analytical Characterization of Innovator and Biosimilar Pair


The CHROMacademy Essential Guide Webcast: Understanding GC Sample Introduction


Editors’ Series: Streamlined Characterization of Antibody–Drug Conjugates by Two-Dimensional (2D) and Four Dimensional (4D) LC–MS


Good Water Practices for Reliable LC–MS and ICP-MS Analyses


Platform Purification Approaches for the Production of Complex Biologics


Access Monoclonal Antibody Quality Attributes with HRMS Analytical Power


 

In a Pickle with Pesticides Sample Prep? Achieve Higher Recoveries with Rapid, Automated Extraction of Any Food Matrix


Non-targeted Screening for Environmental Water Quality Monitoring


Workflows for Released N-Glycan Analysis and Sialic Acid Quantitation of Biotherapeutics


Thermal Desorption-Direct MS: A Breakthrough in Analysis Speed and Throughput


Editors’ Series: Strategies for Improved Pharmaceutical Sample Preparation


In a Pickle with Pesticides Sample Prep? Achieve Higher Recoveries with Rapid, Automated Extraction of Any Food Matrix


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