LCGC Blog

The Lost Art of Fundamental Electronics in Analytical Chemistry

Is the instruction in fundamental electronics and circuit design becoming less central to analytical chemistry education? Or does it remain a core curriculum component. Read more

Features

Moore’s Law in Liquid Chromatography: An Overview of 50 Years of (U)HPLC

This article quantifies the progress in speed and efficiency that has been made in the area of liquid chromatography (LC) over the past 50 years. After a decade of groundbreaking advances in the 1970s, the progress in chromatographic performance over the ensuing four decades (1980–now) follows Moore’s law relatively closely. This is characteristic of technological fields that are of an evolutionary nature (that is, driven by the need for better performance). Read more

Chromatography in the time of COVID-19

Incognito offers some tips for chromatographers during the current crisis. Read more

A Theoretical and Practical Approach to Manage High Peak Capacity and Low Dilution in On-line Comprehensive Reversed-Phase LC × Reversed-Phase LC: A Comparison with 1D-Reversed-Phase LC

On-line comprehensive LC×LC provides much higher separation power than 1D-LC. However, it is also often thought that a larger peak capacity should be obtained at the expense of a higher dilution (lower peak intensity). From a theoretical approach, it is demonstrated that both demands can go hand-in-hand in on-line reversed-phase LC×reversed-phase LC (higher peak capacity and higher peak intensity). Examples involving “sub-hour” separations of a tryptic digest show how this approach can be applied in practice. Read more