LCGC Blog

Experiential Learning Interrupted: Reflecting on Teaching Chromatography During a Pandemic

As our academic year comes to end, I always take time to reflect on what I have learned in the past year. As an assistant professor in Forensic Sciences and Chemistry at Chaminade University of Honolulu, I take the opportunity to review my courses regularly and implement new tools. Some of them will be successful and others will not. Read more

Features

Dried Blood Spots in Mass Spectrometry-based Protein Analysis. Recent Developments including Sampling of other Biological Matrices and Novel Sampling Technologies

This article provides an overview of DBS sampling for mass spectrometry-based protein analysis. The first part will focus on clinical applications for DBSs and on sampling other biological matrices apart from whole blood, including dried matrix spots (DMSs). The second part will explore the new frontiers of the DBS sampling technology, including novel sampling materials/devices, and novel combinations with mass spectrometry. Examples of use in both qualitative and quantitative protein analysis are highlighted as well as examples using both bottom-up and top-down proteomics approaches. Read more

New Gas Chromatography Products for 2019–2020

“GC Connections” presents the column’s annual review of new developments in the field of gas chromatography seen at Pittcon and other venues in the past 12 months. Read more

Glycosylation Analysis Through Released N-Glycan Workflows

Post-translational modifications are potential critical quality attributes (pCQAs) routinely assessed in biotherapeutic development. This article demonstrates the method development considerations for sample preparation and chromatographic analysis of N-glycans of therapeutic mAbs. Read more