LCGC Blog
My initial inclination was to write about something other than the current status of life, given the threats of coronavirus. However, after a month extension to the shelter-in-place was ordered by the U.S. government this past weekend, and after various e-discussions with friends and colleagues throughout the world who are experiencing similar challenges, I felt I might have something to offer to make life easier.
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Features
Two-dimensional liquid chromatography (2D-LC) has recently seen major developments and attracted significant interest. 2D-LC is now viewed as a powerful technique in the “analytical toolbox” and is being widely adopted in the analysis of both small molecules and more complex molecules, specifically biopharmaceuticals. This article will discuss the benefits of 2D-LC and multiple application areas in (bio)pharmaceutical analysis, and will highlight the challenges and future outlook. Read more
This study presents applications of size-exclusion chromatography (SEC) for characterization and quality control of novel biotherapeutic products, including antibody–drug conjugates, hydrophobic proteins, and coformulations. Examples of modifying SEC mobile-phase composition and running conditions to modulate the separation are discussed, as well as approaches and strategies for analyzing atypical protein products such as coformulations.
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This is the third in a series of articles exploring hot topics in high performance liquid chromatography (HPLC). Although originally planned as a preview of the HPLC 2020 conference, which has been postponed to June 2020, the series provides insights into important developments in the technique.
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