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In our February issue:
COLUMNS:
LC TROUBLESHOOTING
Visualizing pH Changes Inside the Column
If you inject a sample buffered at a pH different from that of the mobile phase, how quickly is the sample buffer neutralized inside the column?
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COLUMN WATCH
The Past, Present, and Future of Capillary LC
A discussion on the current state of capillary LC, key drawbacks preventing widespread use, and how these challenges might be overcome. Read more >>
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BIOPHARMACEUTICAL ANALYSIS
Analyzing Novel Biotherapeutics Using SEC
Applications of SEC are presented for characterization and quality control of novel biotherapeutic products, including ADCs, hydrophobic proteins, and coformulations. Read more >>
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| FEATURES: |
2D-LC for Top-Down Protein Analysis
Kevin Schug discusses the advantages of using mobile phases with different pH values in the first and second dimension when using comprehensive two dimensional liquid chromatography (2D-LC) methods for top-down protein analysis.
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| PEER-REVIEWED ARTICLES: |
Paper-Based Sorptive Phases
This article presents the synthesis, types of coatings, and extraction devices, to highlight the versatility and potential of paper-based sorptive phases to the chromatography community, particularly for sample preparation.
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Sampling: The Most Demanding Part of an Analysis
Sampling can be the most demanding part of an analysis. Anybody in charge of sampling needs a good understanding of the composition of the material to be investigated, its heterogeneity (or homogeneity, in simple cases), and the chemical properties of the analytes.
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If you would like to submit an article to LCGC, contact Alasdair Matheson, Editor-in-Chief - amatheson@mmhgroup.com.
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