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May 28, 2020

LCGC Blog

The LCGC Blog: Troubleshooting Gas Chromatography Part II – Reduced Peak Size (Loss of Sensitivity)

We are frequently asked about issues with reduced peak size in gas chromatography (GC), and I’m guessing this is related to just how difficult this problem is to troubleshoot. There are so many potential causes that an inexperienced GC user may not know where to begin the troubleshooting process. Fear not. What follows is our logical guide to locating and fixing the issues with loss of sensitivity, and we’ve tried to cover as many of the instrument and application issues that we can think of. Read more

Applications Collection of solutions by KNAUER

With more than 50 applications at a glance. Find out how the authenticity of vanilla products can be determined or what role liquid chromatography plays in the analysis of cannabinoids. KNAUER´s current applications are now available for download as a PDF file in a specially compiled application compendium. View Here
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Hot Topics in HPLC, Part 6: Chromatographic Innovations for Cell Therapies

This is sixth in a series of articles exploring hot topics in high performance liquid chromatography (HPLC). Read more

Troubleshooting LC Separations of Biomolecules, Part 1: Background, and the Meaning of Inertness

How do bioinert and biocompatible liquid chromatography (LC) systems and columns improve separations of biomolecules? How do I know when these systems are required for my separation? Read more

Tips & Tricks GPC/SEC: Aqueous GPC/SEC for Water-Soluble Macromolecules

Water-soluble macromolecules require water as a mobile phase, and method development therefore seems to be straightforward. At second glance, however, aqueous gel permeation chromatography/size-exclusion chromatography (GPC/SEC) is complex and the choice of the stationary phase and pH are crucial. In addition, mobile phase additives are often required to allow for interaction-free separations. Read more

NEWS

Nitrosamine Determination Using GC–PCI-QTOF-MS

Researchers have developed an alternative method to reduce interferences for the analysis of N-nitrosamines using GC coupled to HR-QTOF-MS. Read more

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LCGC Blog

The LCGC Blog: Troubleshooting Gas Chromatography Part II – Reduced Peak Size (Loss of Sensitivity)

Applications Collection of solutions by KNAUER

Hot Topics in HPLC, Part 6: Chromatographic Innovations for Cell Therapies

Troubleshooting LC Separations of Biomolecules, Part 1: Background, and the Meaning of Inertness

Tips & Tricks GPC/SEC: Aqueous GPC/SEC for Water-Soluble Macromolecules

NEWS

Nitrosamine Determination Using GC–PCI-QTOF-MS

FEATURED PRODUCTS

Runge Mikron Detectors

Compliant GPC/SEC - IPC- 2D Software

A powerful new tool for characterization of charged species

Upcoming Webcasts

Toxicology Screening Using High Resolution Mass Spectrometry for Forensic Cases

Routine Lab Procedures Are Easy to Apply to Direct MS

Faster, Simpler Method Validation with Direct MS, in Compliance with Regulatory Guidelines

Direct MS Simplifies Analysis of Challenging Compounds

ON DEMAND WEBCASTS

Editors’ Series: Considering Speed and Throughput in HPLC Sample Preparation

Why Labs and CROs Should Adopt Direct MS

Automated Online µSPE Cartridge Clean-up of QuEChERS Extracts before LC–MS/MS and GC–MS/MS Analysis of Pesticides in Foods

Analyte Binding Following Sample Filtration in HPLC: Causes, Effects, and Solutions

Practical Method Development Strategies for the Analysis of Monoclonal Antibodies by Reversed-Phase HPLC

Five Essentials for Surviving Your Next Laboratory Inspection: A Quality Control Example

Advances in Gas Chromatography for Separation of Challenging Analytes in the Pharmaceutical, Environmental, Cannabis, and Food Industries

How to Build a Cannabis Testing Laboratory

Implementing Attribute Monitoring Analyses for Biopharmaceutical Development and QC

Setting Up a GC Instrument for Analysis

Pesticide Analysis Using a GC-Triple Quadrupole Mass Spectrometer

GC Method Advancements for the Analysis of Environmental Matrices in the Industrial Landscape

Dealing with COVID-19: Longer-term Shutdown and Startup Considerations in the Chromatography Laboratory

Editors’ Series: Limiting Laboratory Exposure: A Chemist’s Guide to the COVID-19 Outbreak

Editors’ Series: Coping with COVID-19: Remaining Productive and Safe in the Analytical Laboratory

Improve Productivity through Automated Ion Chromatography (IC)

Multi-Level Workflows for Quantitative N-Glycan and Sialic Acid Analysis of Biotherapeutics

Understanding Oligonucleotides from Every Angle: Utilizing Mass Spectrometry for Characterization and Quantification

Complete Workflow Solutions for Analyzing Complex Food Samples Using SPME

Editors’ Series: The CHROMacademy Essential Guide to: HPLC Method Troubleshooting