LCGC ASIA PACIFIC, News Update
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LCGC Asia
March 24, 2020
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FEATURES

Molecular Weight Analysis of Glatiramer Acetate and Related Compounds by Size-Exclusion Chromatography with Multi-Angle Light Scattering Detection (SEC-MALS)

A method was developed for the molecular weight characterization of heterogeneous polymer mixtures, such as heparins and glatiramer acetate, noting that single molecular structures are not adequate for creating a molecular weight calibration curve. That limitation is overcome in this work, which demonstrates method validation and application to process samples. Read more


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Multi-angle static light scattering

The DAWN is the world’s most advanced multi-angle static light scattering (MALS) detector for absolute characterization of the molar mass and size of macromolecules and nanoparticles in solution. DAWN offers high sensitivity, a wide range of molecular weight, size, and concentration, and a large selection of configurations and optional modules for enhanced capabilities. Learn More


Methods and Purposes for Determining Higher Order Structures of Biopharmaceuticals

The determination of higher order structures of biopharmaceuticals has become an important subject for biopharmaceutical firms and regulatory agencies. This overview covers the important approaches, as described in recent books, journals, and magazine articles, and scientific meetings. Read more

Effects of Flow Rate on UV Detection in Liquid Chromatography

A deeper theoretical understanding of the relationship between peak area and flow rate will help analysts diagnose problems when using UV absorbance detection. Read more


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On-line Differential Viscometer

The ViscoStar® incorporates multiple novel technologies to provide the highest sensitivity, stability and solvent compatibility of any available viscometer for GPC. Its ease-of-use and serviceability make it the perfect companion for Wyatt's DAWN® light scattering and Optilab® refractive index detectors. Learn More


Application Notes

Polymer Branching Analysis by SEC-MALS-IV

Branching impacts polymer properties such as rheology and stiffness. This note explains the analysis of branching ratio versus molar mass, accomplished by SEC-MALS(-IV).
/ Download the application note /

Analysis of Hyaluronic Acid by SEC-MALS-IV

Comprehensive physicochemical characterization of biopolymers is accomplished by adding multi-angle light scattering and differential viscometry to standard SEC.
/ Download the application note. /


FEATURED PRODUCT

DAWN MALS Detector

The world's most advanced light scattering instrument for absolute characterization of molar mass and size of macromolecules and nanoparticles in solution.
/ Learn More /


ViscoStar Differential Refractometer

A highly sensitive, on-line differential viscometer used in conjunction with SEC-MALS to determine the size and conformation of all types of biopolymers, synthetic polymers and even proteins and peptides.
/ Learn More /


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