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Strategies for Upstream Intensification: The Seed Train
Upstream processes can be intensified using a number of strategies which can deliver significant improvements in speed, flexibility and reliability. In this white paper, we explore two of these approaches: high cell density cryopreservation (HCDC), and the use of a perfused seed train including a specially designed expansion medium.
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Specially designed expansion medium for your perfused seed train
Our new Cellvento® 4CHO-X Expansion Medium supports cell expansion including N-1 perfusion for Chinese Hamster Ovary (CHO) cell lines. It is formulated with a high nutrient concentration to achieve low cell specific perfusion rates (CSPRs) at high cell densities. The medium is chemically defined, of non-animal origin, and contains no hydrolysates or components of unknown composition.
Best Regards,
Your Merck Team
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The life science business of Merck operates as MilliporeSigma in the U.S. and Canada.
Merck, the vibrant M and Cellvento are trademarks of Merck KGaA, Darmstadt, Germany or its affiliates. All other trademarks are property of their respective owners. Detailed information on trademarks is available via publicly accessible resources.
© 2020 Merck KGaA, Darmstadt, Germany and/or its affiliates. All Rights Reserved.
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