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Current balancing act

A consistent and uniformly glycosylated protein is a key criterion in biotherapeutics manufacturing. It would be nice if you also produced your glycosylated protein at high levels. Traditionally, glycosylation is achieved by optimizing a cell line as well as varying culture conditions. In doing so, you may give up protein yield in order to produce the desired glycopattern.

In vitro glycoengineering (IVGE)

In vitro glycoengineering allows you to uncouple the need to balance between yield and glycosylation. First you selecting clones that give maximum yield then after producing your protein you can selectively glycosylate it by in vitro glycoengineering (IVGE) resulting in a complete and consistent end product.

Roche CustomBiotech has developed enzymes for galactosylation and sialylation along with their substrates. Using these enzymes you can simply galactosylate your protein or generate fully sialylated proteins, depending on your therapeutic need.

• Simple "one pot operation"

• Works on a variety of antibodies and proteins

• Provides complete and consistent glycoform patterns

• Doesn’t cause aggregation of the proteins tested *

• Shortens the timeline by at least 30% and increases the production yield by >160% *

• Reduces indirect (e.g. FTEs) and direct costs (e.g. reagents) during scale up *

• Allows selective galactosylation or sialylation of your protein

7 grams of starting material processed in a single pot reaction

Reagents for development and production

CustomBiotech portfolio offers the necessary reagents for IVGE. Roche CustomBiotech has implemented process improvements in manufacturing of these enzymes and sugars keeping in mind that these critical raw materials need to be supplied to you in a cost effective manner, when you employ IVGE strategy for large scale biotherapeutics production.

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