Increase Cell Culture Productivity With Real-Time CO₂ Control

Download the guide, "5 Ways In-Line CO2 Sensors Improve Bioprocessing" to learn more.

CO₂ measurement and control is important in cell culture, as excess levels can be toxic to the cells and can affect the quality of protein products. Specifically, as aerobic mammalian cells grow they consume nutrients and O₂ and excrete CO₂, ammonia and lactic acid.

As cells continue to proliferate, the concentration of excreted CO₂ increases and can lead to an overall drop in pH, which is can have an unfavorable effect on further cell growth.

This guide highlights how real-time CO₂ control can be achieved, and the impacts it can have on bioprocessing yield.

Stories in the guide include:

• How management of CO₂ accumulation can increase productivity
• How in-line CO₂ sensors can support process development from the benchtop to production vessels
• How CO₂ can be used to help monitor respiratory efficiency.