Polishing of monoclonal antibodies using Capto adhere ImpRes in bind and elute mode

Capto adhere ImpRes is a strong ion exchanger with multimodal functionality designed for polishing of monoclonal antibodies (MAbs). In this study, the binding capacity for MAbs and the efficiency in the clearance of impurities using Capto adhere ImpRes in bind/elute (B/E) mode was evaluated. The study presents results from optimization of the loading conditions using the Design of Experiments (DoE) approach.
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A Polished Performance in MAb Purification

Multimodal chromatography media (resin), e.g., the new Capto™ adhere ImpRes, has been proven very successful in the polishing steps of monoclonal antibodies (MAbs). Selection of buffer composition and salt could have an impact on the performance of such purification steps. Read more about developments in the verification of these new chromatography media.
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