THE BAKER'S DOZEN: THIRTEEN OF THE BEST ARTICLES FROM 2018

With the arrival of the new year, what better time to reflect on 2018 and look back at some of the most-popular articles from LCGC Europe and The Column that attracted readers' attention last year? These articles illustrate the wide range of content we provide offering practical advice, technical expertise, unique insights, and the latest trends in separation science.

3. Do Chromatographers Need More Automation?

Incognito asks if chromatographers are behind the curve when it comes to automation. Read more

4. The LCGC Blog: Multipath Liquid Chromatography–Mass Spectrometry: A Veritable Pandora's Box

Kevin Shug discusses his group's work on a concept that they have termed multipath liquid chromatography (LC). Read more

5. Nontargeted Screening Approaches for Potential Food Adulterants and Contaminants

Ann M. Knolhoff, a researcher for the U.S. Food and Drug Administration, spoke to LCGC Europe about the development of nontargeted screening approaches for potential contaminants and adulterants in food, and the considerations around sample preparation, chromatography, mass spectrometry, and data processing workflows. Read more

6. Recent Advances in Hyphenated Chromatography and Mass Spectrometry Techniques and Their Impact on Late-Stage Pharmaceutical Development

The changing role of mass spectrometry (MS) hyphenated to reversed-phase liquid chromatography (LC) and alternative separation techniques in late-stage pharmaceutical development is discussed. Read more

7. A Practical Approach to Modelling of Reversed-Phase Liquid Chromatographic Separations: Advantages, Principles, and Possible Pitfalls

Chromatographic principles and best practices for obtaining highly precise retention time, peak width, and resolution predictions for the optimization of reversed-phase liquid chromatography (LC) separations using retention modelling software is discussed. Read more

8. Tips, Tricks, and Troubleshooting for Separations of Biomolecules, Part 1: Contemporary Reversed-Phase Protein Separations

Several new materials and columns have been introduced in recent years for reversed-phase separations of proteins. How do you know which one to choose, and which separation conditions will be best for your protein separation? Read more

9. Highlights from the HPLC 2018 Symposium

The 47th International Symposium on High Performance Liquid Phase Separations and Related Techniques (HPLC 2018), chaired by Norman Dovichi, was held from 29 July to 2 August in Washington, D.C., USA. This instalment of "Column Watch" covers some of the highlights observed at the symposium. Read more

10. A Look Back and A Look Forward–An Annual Check up on the State of Sample Preparation

In the final "Sample Prep Perspectives" column of the year, it is fitting to assess the state of the field by taking a look back and a look forward. Read more

11. The Benefits of AQbD

The Column spoke to Changqin Hu and Xia Zhang from the National Institutes for Food Drug Control, in Beijing, China, about their work developing a dual-gradient elution stability-indicating method for cloxacillin within an analytical quality by design (AQbD) framework. Read more

12. New HPLC Systems and Related Products Introduced in 2017–2018: A Brief Review

This instalment of "Perspectives in Modern HPLC" describes high performance liquid chromatography (HPLC) and related products introduced at Pittcon 2018 in Orlando, Florida, USA, and in the year prior. Read more

13. A LEAN Approach for the Determination of Residual Solvents Using Headspace Gas Chromatography with Relative Response Factors

This study demonstrates a new LEAN approach and method, where 25 solvents can be simultaneously determined based on predetermined relative response factors (RRFs) against an internal standard (decane) with only one injection of sample solution. Read more

Chiral Screening for SFC and UHPLC

This application shows chiral method development for both SFC and UHPLC using the Agilent 1260 Infinity II SFC/UHPLC Hybrid System with software aided method scouting. / Download Application Note /

NEW! Ultra-High Purity Nitrogen Generator

NEW from VICI DBS, the ultra-high purity nitrogen generator for all GC applications. With a flow rate of 200 ml/min and <0.1ppm THC, it is ideal for ECD and carrier gas.
/ Read more /

µPAC™ - Next-level chromatography

PharmaFluidics' game-changing chip-based chromatography column for nano-LC, lets you detect more molecules in tiny, complex biological samples: excellent separation, unprecedented robustness and reproducibility, perfect for lipidomic, metabolomic and peptide profiling. / Read more /

NEW SEC Column for Antibodies

The new YMC-SEC MAB is designed for analysing antibodies, fragments or aggregates. It is the ideal choice for high resolution of high and low molecular weight species with excellent reproducibility. / Read more /

Triple Detection

Postnova introduces the powerful Triple Detection for Thermal Field-Flow Fractionation (FFF) and GPC/SEC. ribution, molecular size distribution and molecular structure (branching, comTriple Detection is the combination of Multi-Angle Light Scattering (MALS), Viscosity Detection, Refractive Index Detection and UV Detection. In a single separation experiment Triple Detection provides molar mass distposition) of polymers, biopolymers, polysaccharides, proteins and antibodies. / Read more /