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Featured Application Note:
Online SPE Analysis of Oestrogens in Drinking Water
Bettina Schuhn, Agilent Technologies
This work demonstrates the enhanced sensitivity of the Agilent 1200 Infinity Series Online SPE Solution compared to direct inject methods on a routine and a high-end mass spectrometer. Read More |
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The Analysis of Chlorinated Dioxins and Difurans in Pet Food
Philip Bassignani, FMS, Inc.
Screening for chlorinated dioxins and difurans in human supplies is a well-established practice. However, there is a growing concern for pet safety highlighted by recent contamination issues in pet food, such as the 2007 melamine incident. The following outlines procedures for processing canned dog food for chlorinated dioxin and difuran analysis via EPA 1613. Read More |
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Extraction of THC, THCA, and Carboxy-THC by ISOLUTE SLE+ from Oral Fluid Prior to GC–MS Analysis
Rhys Jones, Biotage AB, Sweden
This application note describes the extraction of THC, THCA, and Carboxy-THC from oral fluid matrix collected using the Intercept Oral Fluid Drug Test Kit (Orasure Technologies), prior to GC–MS analysis. In this application note an effective and efficient ISOLUTE SLE+ protocol has been optimized for 400-µL and 1-mL sample capacity formats. Read More |
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Using a QuEChERS Approach for the Determination of Pesticide Residues in Soil
Brian Kinsella, UCT, LLC.
The use of pesticides is widespread. To ensure food safety and limit unnecessary exposure it is important to test for pesticide residues. Due to the wide range of pesticides used, the development of fast multi-residue methods is essential. This application note outlines a QuEChERS extraction screening method for 21 pesticides in soil. Read More |
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Modernizing the USP Monograph for Impurity Profiling of Metoprolol Tartrate
Rongjie Fu, Agilent Technologies
A HPLC method using Agilent Poroshell 120 EC-C18 and Poroshell 120 Phenyl-Hexyl columns was developed, using a gradient and a mass spectrometer friendly buffer of ammonium acetate in water and acetonitrile. Degraded compounds can easily be separated and detected using this method. Read More |
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Ion Chromatography — A Versatile Tool in Pharma Analysis
Stephanie Kappes, Alfred Steinbach, and Katinka Ruth, Metrohm
Ion chromatography is a flexible technique with a wide variety of practical uses in the pharma sector. Take a look here at some pertinent trends and recent advances in its application. Read More |
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HILIC Separation of Nucleobases
Tosoh Bioscience
In medicine, several primary nucleobases are the basis for synthetic analogues that are used as anticancer and antiviral agents. This application note demonstrates the benefits of using a TSKgel SuperSW mAb HTP (U)HPLC column in HILIC mode for the superior resolution of four nucleobases, as opposed to using the column in SEC mode or using a HILIC column. Read More |
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Analysis of Positional Isomers with Agilent Poroshell 120 PFP Columns
William Long and Jonathan Horton, Agilent Technologies
The Agilent Poroshell 120 PFP chemistry can give greater retention and selectivity for positional isomers of halogenated compounds. PFP columns can also be used for selective analysis of non-halogenated compounds. In this application note, the separation of three positional isomers of trimethoxybenzene and dinotrobenzene is accomplished using an Agilent Poroshell 120 PFP column. In addition, the separation of 14 explosive compounds listed in EPA 8330 is shown. Read More |
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Food Authenticity – Classification of Coffee Types Based on LC–MS
Verena Tellström, Sven Brand, Michael Becker, Klaus Meyer, Gabriela Zurek, and Aiko Barsch, Bruker Daltonics
Traditionally, standard assays for food testing are based on measurements of a relatively small number of target compounds or characteristic features. Recent advances in LC–MS technology have enabled simultaneous measurement of many compounds in parallel and without prior knowledge of sample constituents (a non-targeted approach). In the case of small molecule analysis, this is typically referred to as metabolomics or metabolic profiling. MS and NMR are the most widely used complementary instruments for detecting possible authenticity-defining compounds and adulterants.
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Leveraging Organizational Information with Scientific Search
Waters Corporation
Information technology in a science-driven organization has been very effective at capturing, storing, and archiving information, driven in part by regulatory pressures. However, the inability to gain better access and higher value to the relevant information they already own is a common and costly struggle due principally to three problems. This white paper, Scientific Search in the Science-Based Organization, will address these three problems and introduce a new generation search solution for accessing scientifically relevant information across an entire organization. Read More |
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