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Featured Application Note:
Determination of Ochratoxin A in Roasted Coffee
Edgar Naegele, Agilent Technologies
This application note demonstrates the determination of the mycotoxin ochratoxin A in roasted coffee products according to DIN EN 14132. Additionally, the improvement of the standard method will be demonstrated. Read More |
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Fully Automated Solid Phase Extraction of Base, Neutral, and Acid Semivolatiles in Industrial Waste Water
Phillip Bassignani, FMS, Inc.
Traditionally involving six LLE shakes at both pH 2 and 12 (plus heavy emulsions and low recoveries), traditional base, neutral, and acid for semivolatiles extractions are time-consuming and often lead to poor results. By incorporating automated SPE with multi-bed sorbents, base, neutral, and acid for semivolatiles samples can be extracted with a single pass procedure without emulsions, centrifuging, and hours of manual labor. The FMS TurboTrace ABN SPE system is designed to handle multiple cartridges and provides a fully automated solution for the semivolatile extraction process. Read More |
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Analysis of THC and Metabolite Suite from Oral Fluid Using ISOLUTE SLE+ Prior to LC–MS-MS
Kerry Stephens, Biotage
The method described in this application note achieves high recoveries of THC and an extended suite of common metabolites in oral fluid from Quantisal™ oral fluid collection devices using ISOLUTE SLE+. This application note describes effective and efficient ISOLUTE SLE+ protocols optimized for sample loading volumes of either 300 μL or 800 μL. The simple sample preparation procedure delivers clean and reproducible results. Read More |
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Determination of Amphetamines in Urine Samples Using Solid Phase Extraction and LC–MS-MS
Jeffery Hackett, UCT, LLC
Amphetamines are a class of drugs that stimulate the central nervous system producing an increase in alertness, wakefulness, and awareness. Traditionally, amphetamines screening is often accomplished by immunoassay followed by either GC–MS or LC–MS for confirmation or quantitation. This method uses a mixed-mode SPE extraction followed by LC–MS-MS analysis using a PFPP HPLC column. Read More |
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Arsenic Speciation by HPLC–ICP-MS with High-Sensitivity Ion Focusing and Nitrogen-Enriched Plasma
Andrew Toms, Peio Riss, and Søren Dalby, Bruker Daltonics
The effects of nitrogen addition to an argon plasma for ICP-MS analysis have been extensively studied over many years in numerous applications for elemental analysis, but without resulting in widespread commercial or regulatory acceptance. Recent research at Bruker, combined with simple integration of this technique into current and existing hardware, shows some renewed promise for this application, with potential for significant cost-benefit advantage. Read More |
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Identification of Colour Additives in Food
Silke Ubben, Gilson
In this application, AOAC method 988.13 was automated using a Gilson GX-274 ASPEC to perform the SPE process just prior to automated spectrum analysis using an Agilent 8453 UV-visible Spectrophotometer with an Agilent 8-position Multicell. Read More |
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Improving Productivity in Purifying Antroquinonol Using UPC2 and Prep SFC
Rui Chen. John McCauley, Jo-Ann Jablonski, Carol Fang, and Jacquelyn Runco, Waters Corporation
The supercritical fluid-based techniques, UPC2 and prep SFC, augment the conventional toolbox for natural product research by offering complementary selectivity to RPLC, and enable laboratories and manufacturers in pharmaceutical, traditional medicine, nutraceutical, and dietary supplement industries with more efficient and more cost-effective natural product purification. Read More |
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Rapid Analysis of Environmental Contaminants by Fast GC–TOF MS with Select-eV Variable-Energy Electron Ionization
Laura McGregor, Nick Bukowski, and Gareth Roberts, Markes International
This application note shows that BenchTOF time-of-flight mass spectrometers provide a robust, high-performance and high-throughput solution for screening multiple trace-level environmental contaminants by GC–MS. Revolutionary variable-energy electron ionization is also shown to aid compound identification and enhance the selectivity and sensitivity of analyses by generating secondary (qualifying) mass spectra with reduced fragmentation and a stronger molecular ion signal. Read More |
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