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A Rapid Screening Method for Analysis of Multi-Class Antibiotics from Ground Meat (Sausage) Using QuEChERS and LC–MS–MS
Sueki H. Leung, Xianrong (Jenny) Wei, Allen Misa, and Jeff Layne, Phenomenex
The purpose of this study was to develop a rapid, robust, and sensitive multi-class screening method for the detection of antibiotics in ground meat samples at maximum residue limit levels defined by Commission Regulation (EU) No 37/2010. Read More |
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Ultra-Selective High Resolution LC–MS–MS Determination of Phenylbutazone in Ground Meat
Sueki H. Leung, Jenny Wei, Shahana Huq, and Seyed Sadjadi, Phenomenex
A simple yet effective solid phase extraction and cleanup method for phenylbutazone from meat with recovery values >90%. Highly specific LC–MS–MS data is generated using a Kinetex® 2.6 µm XB-C18 core-shell column enabling rapid run times under 5 min with excellent precision and accuracy. Read More |
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Improved Analytical Method for the LC–MS–MS Analysis of Chloramphenicol in Shrimp
Philip J. Koerner, Matthew Trass, Liming Peng, and Jeff Layne, Phenomenex
A method for the analysis of chloramphenicol in shrimp has been developed with a limit of quantitation (LOQ) of 0.001 ng/g in shrimp (0.001 ppb) based on the calibration standards. This is 300 times lower than the current United States Food and Drug Administration (US FDA) method. Read More |
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Rapid LC–MS–MS Analysis of Antibiotics in Meat for Human Consumption
YunYun Zhou, Dave Lavorato, Terrell Mathews, and Sky Countryman, Phenomenex
Rapid analysis of seven classes of antibiotics from meat products in less than 8 min results in shorter cycle times and improved productivity. Ultra-high efficiency Kinetex core-shell columns provide narrower peaks and increased sensitivity. Read More |
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Sample Preparation Method Development for Complex Matrices Such as Foods
Sueki Leung, Erica Pike, and Allen Misa, Phenomenex
The lack of proper sample preparation in food analysis can lead to major instrumentation and analytical challenges downstream and a substantial amount of time may be required to develop or optimize a sample preparation method. In this technical note, we will evaluate the use of two sample preparation techniques commonly used in food analysis, QuEChERS and solid phase extraction (SPE). Additionally we will discuss tips and considerations to streamline the method development and optimization process. Read More |
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Pesticide Residues Analysis of Spinach Using QuEChERS by LC–MS–MS and GC–MS
Sueki H. Leung, Monika M. Kansal, Carl Sanchez, Art Dixon, Michael Rummel, and Erica Pike, Phenomenex
Pesticide residue analysis of spinach by LC–MS–MS, GC–MS, and QuEChERS. Quickly and effectively removes pigments and other matrix interferences from the difficult spinach sample. The lower limit of quantification (LLOQ) was well below the international maximum residue level limit reported. Read More |
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A Fast and Effective Approach to Analyzing Hormones in Drinking Water Using SPE and LC–MS–MS
Sueki H. Leung, Jenny Wei, Matthew Trass, Ali Haghani, and Andy Eaton, Phenomenex
A method is illustrated for steroid hormone analysis from drinking water using an optimized LC–MS–MS method, reducing analysis time from 50 min down to about 15 min while maintaining excellent linearity (0.99 R2 value or greater for each compound) and low minimum reporting level MRLs. The method presented uses a Gemini® 3 µm NX–C18 HPLC column, which delivers stability at pH 1–12. Read More |
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HPLC-UV Analysis of Gingerol in Ginger Root per cGMPs for Dietary Supplements
Zeshan Aqeel, J. Preston, Jeff Layne, and Steve Baugh, Phenomenex
Identity testing of raw materials for potency and verification of label claim data in nutraceutical formulations are requirements of dietary supplement cGMPs. The complex nature of nutraceuticals and botanicals often requires long analysis and difficult sample cleanup steps to resolve matrix interferences. In this technical note, we optimize our pre-existing method to reduce total analysis time using newer high efficiency HPLC technologies and evaluate the quantitative results obtained by using newly available gingerol and shogaol reference standards versus a traditional quantitation. Read More |
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HPLC-UV Analysis of Vitamin C from Tablets and Soft-Gels per cGMPs for Dietary Supplements
Shuguang Li and Steve Baugh, Phenomenex
The verification of label claim data in nutraceutical formulations has come under scrutiny by the FDA. Manufacturers and contract testing labs alike are looking for accurate and scientifically valid methods that are suitable for use with different formulations. In this technical note, we determine an accurate and reproducible means of analyzing vitamin C and demonstrate the suitability for analysis of two commercially available formulations of vitamin C. Read More |
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