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In our December issue:
COLUMNS
LC TROUBLESHOOTING
 Column Protection in Three Easy Steps
 Can you make your column last forever? Not quite, but John Dolan can help you to prevent its early demise.
SAMPLE PREPARATION PERSPECTIVES
 Understanding and Improving Solid-Phase Extraction
 In this instalment of “Sample Prep Perspectives” some of the basic scientific principles behind SPE that allow the correct mode of extraction to be selected are discussed.
MS — THE PRACTICAL ART
 Quantifying Small Molecules by MS
 The use of a mass spectrometer in quantitative analysis exploits its selectivity and sensitivity as a detector, allowing a signal to be attributed to a particular chemical entity with high certainty, even when present in a sample at a low concentration. There are some considerations that must be kept in mind when a mass spectrometer is used as a quantitative tool. This instalment of “MS – The Practical Art” discusses the general precepts of quantitative analysis, as well as the concept of “Fitness for Purpose”.
BIOTECHNOLOGY TODAY
 The Role of Elution Gradient Shape in the Separation of Protein Therapeutics
 The role of the gradient in the separation of protein therapeutics by reversed phase and ion-exchange HPLC is discussed. Data from two products are presented to illustrate the key points.
THE ESSENTIALS
 A Blueprint to Developing Better GC Methods
 A guide to developing better GC Methods from CHROMacademy.com.
PEER-REVIEWED ARTICLES
 A Single-Method Approach for the Analysis of VOCs and SVOCs in Air Using Thermal Desorption Coupled with GC–MS
 This article describes a new, single method to replace the two method approach using United States EPA Methods TO-15 and TO-13A for the analysis of both VOCs and SVOCs in air.
How Suitable is a Green Solvent for GPC and TREF Analyses of Polyethylene?
 This study presents results of gel permeation chromatography (GPC) and analytical temperature rising elution fractionation (TREF) of polyethylene in butaylal.
LC Methods for the Separation of Short RNA Oligonucleotides
 A review of LC methods and strategies for the chromatographic separation of short RNA oligonucleotides.
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