A History of Advances in Preventing Organ Rejection
Advances in immunosuppressive medicine have affected the alloimmune response mechanism that triggers organ rejection in renal transplantation. Appreciating these advances requires an understanding of the targets of some of the older and current immunosuppressive agents, as well as those currently in development.
Upon completion of this interactive, self-guided tutorial, participants should be able to discuss the clinical evidence that drove the shift from calcineurin inhibitors and steroids to regimens that include biologic agents; understand the roles of inflammation and inflammatory mediators in graft rejection (acute and chronic), and discuss the role of biologic inhibitors in mediating this process; and identify approved and developmental agents for graft rejection and discuss their targets, relative efficacies, and safety profiles in monotherapy or combination therapy for the management of rejection.
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